Implantable prosthesis with radiopaque particles and method of making same

Patent metadata

Field	Value
Publication number	US-9539125-B2
Application number	US-201514858336-A
Country	US
Kind code	B2
Filing date	Sep 18, 2015
Priority date	Jun 26, 2012
Publication date	Jan 10, 2017
Grant date	Jan 10, 2017

Abstract

An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.

First claim

What is claimed is:

1. A method of making an implantable prosthesis, the method comprising:
placing radiopaque particles within a lumen of a strut having a plurality of side holes extending from the lumen to an exterior surface of the strut, the radiopaque particles having sizes that prevent the radiopaque particles from passing through the side holes,
wherein placing the radiopaque particles within the lumen includes placing some of the radiopaque particles directly below the side holes.

2. The method of claim 1 , further comprising forming the side holes by drilling or milling a metal wall of the strut.

3. The method of claim 1 , wherein each of the side holes has a central axis that is non-parallel with a central axis of the lumen, and the central axis of the side hole is at a non-zero angle relative to the central axis of the lumen.

4. The method of claim 1 , wherein each of the radiopaque particles has an outer diameter, a metal wall of the strut defines an inner diameter of the lumen, and the inner diameter of the lumen is greater than the outer diameter of each of the radiopaque particles.

5. The method of claim 1 , wherein each side hole is in the shape of an elongated slot or oval, each side hole has a minor diameter and a major diameter, and an outer diameter of each radiopaque particle is greater than the minor diameter and less than the major diameter.

6. The method of claim 1 , further comprising introducing a therapeutic agent in the lumen, wherein the therapeutic agent is capable of escaping from the lumen through the side holes.

7. The method of claim 1 , wherein the placing of the radiopaque particles within the lumen includes introducing the radiopaque particles through an end hole of the strut.

8. The method of claim 7 , further comprising crimping, sealing or plugging the end hole after the introducing of the radiopaque particles through the end hole.

9. The method of claim 7 , further comprising forming the side holes through the strut before the introducing of the radiopaque particles through the end hole.

10. The method of claim 7 , further comprising forming the side holes through the strut after the introducing of the radiopaque particles through the end hole.

11. A method of making an implantable prosthesis, the method comprising:
placing radiopaque particles within a lumen of a strut having a plurality of side holes extending from the lumen to an exterior surface of the strut, the radiopaque particles having sizes that prevent the radiopaque particles from passing through the side holes,
wherein the placing of the radiopaque particles within the lumen includes introducing the radiopaque particles through an end hole of the strut.

12. The method of claim 11 , further comprising crimping, sealing or plugging the end hole after the introducing of the radiopaque particles through the end hole.

13. The method of claim 11 , further comprising forming the side holes through the strut before the introducing of the radiopaque particles through the end hole.

14. The method of claim 11 , further comprising forming the side holes through the strut after the introducing of the radiopaque particles through the end hole.

15. The method of claim 14 , wherein forming the side holes is performed by any of drilling the strut, chemical etching the strut, and milling a metal wall of the strut.

16. The method of claim 11 , wherein the end hole has a central axis coaxial with a central axis of the lumen.

17. The method of claim 11 , further comprising forming the side holes by drilling or milling a metal wall of the strut.

18. The method of claim 11 , wherein each side hole is in the shape of an elongated slot or oval, each side hole has a minor diameter and a major diameter, and an outer diameter of each radiopaque particle is greater than the minor diameter and less than the major diameter.

19. The method of claim 11 , further comprising introducing a therapeutic agent in the lumen, wherein the therapeutic agent is capable of escaping from the lumen through the side holes.

Assignees

• Abbott Cardiovascular Systems Inc

Inventors

• Pacetti Stephen

Classifications

• A61F2230/0069

  cylindrical · CPC title

• A61F2250/0098

  radio-opaque, e.g. radio-opaque markers · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61F2/915 Primary

  with bands having a meander structure, adjacent bands being connected to each other · CPC title

• A61F2250/0067

  Means for introducing or releasing pharmaceutical products into the body · CPC title