Tetrazole derivatives
US-2024382468-A2 · Nov 21, 2024 · US
Substituted sodium-1H-pyrazole-5-olate
US9533972B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9533972-B2 |
| Application number | US-201113988141-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 15, 2011 |
| Priority date | Nov 18, 2010 |
| Publication date | Jan 3, 2017 |
| Grant date | Jan 3, 2017 |
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- Title
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Abstract
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The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.
First claim
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The invention claimed is: 1. A method of treating a medical condition or disease that is treatable by the inhibition of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase, wherein the medical condition or disease is cardiovascular diseases, cardiac insufficiency, anaemia, chronic kidney diseases or renal insufficiency, the method comprising administering to a human or animal in need thereof a therapeutically effective amount of the compound Sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1 -y 1 )-1H-pyrazol-5-olate corresponding to the compound of the formula (II) 2. A method of treating a medical condition or disease that is treatable by the inhibition of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase, wherein the medical condition or disease is cardiovascular diseases, cardiac insufficiency, anaemia, chronic kidney diseases or renal insufficiency, the method comprising administering to a human or animal in need thereof a therapeutically effective amount of the pharmaceutical composition comprising the compound, Sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate corresponding to the compound of the formula (II) in combination with an inert, non-toxic, pharmaceutically suitable auxiliary. 3. A method of treating a medical condition or disease that is treatable by the inhibition of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase, wherein the medical condition or disease is cardiovascular diseases, cardiac insufficiency, anaemia, chronic kidney diseases or renal insufficiency, the method comprising administering to a human or animal in need thereof a therapeutically effective amount of the pharmaceutical composition comprising the compound, Sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate corresponding to the compound of the formula (II) in combination with a further active compound. 4. The method of claim 1 , wherein the compound of formula (II) is present in crystalline form. 5. The method of claim 2 , wherein the compound of formula (II) is present in crystalline form. 6. The method of claim 3 , wherein the compound of formula (II) is present in crystalline form. 7. The method of claim 1 , wherein the cardiovascular disease is coronary heart disease, angina pectoris, myocardial infarction, stroke, arteriosclerosis, essential hypertension, pulmonary hypertension, malignant hypertension, or peripheral arterial occlusive disease.
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Classifications
Antihypertensives · CPC title
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for disorders of the blood or the extracellular fluid · CPC title
Drugs for disorders of the cardiovascular system · CPC title
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- What does patent US9533972B2 cover?
- The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, …
- Who is the assignee on this patent?
- Militzer Hans-Christian, Gries Jörg, Koep Stefan, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D403/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 03 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).