System and method for monitoring patient condition using atrial timing characteristics

Patent metadata

Field	Value
Publication number	US-9533158-B2
Application number	US-33317608-A
Country	US
Kind code	B2
Filing date	Dec 11, 2008
Priority date	Dec 11, 2008
Publication date	Jan 3, 2017
Grant date	Jan 3, 2017

Abstract

A system and method for using an implantable cardiac stimulation device to monitor a patient for the progress of an existing condition and/or early detection of an emerging condition based, at least in part, on measuring and evaluating the timing characteristics of the patient's atrial activity. The atrial timing characteristics are used as indicators or predictors of conditions of interest, such as heart failure (HF) and atrial fibrillation (AF). In certain implementations, the system can determine discriminating indicators of a predominant underlying cause of a condition, such as between vagal and non-vagal AF, as an indicator of a suggested therapy. The system can store data corresponding to the observed atrial timing for trending analysis as well as transmit data for offline analysis, such as via an external device.

First claim

What is claimed is:

1. A method of evaluating a patient's condition via use of an implantable cardiac therapy device, the method comprising: sensing a patient's cardiac activity, including activity of the atria, via the therapy device;
determining an interatrial conduction delay via the device;
storing the interatrial conduction delay in memory of the device;
comparing a record of the interatrial conduction delay over time with a corresponding threshold as a surrogate indicator of atrial fibrillation
determining whether any change indicated warrants active notification of the change, and
delivering a notification signal to alert at least one of the patient and attending clinical personnel of the indicated change when active notification is warranted;
delivering stimulation to the heart by a lead based on the comparison of the record.

2. The method of claim 1 , wherein the at least one patient condition comprises a known disease condition and wherein the change comprises a defined variation of the interatrial conduction delay from a previously determined value of the interatrial conduction delay.

3. The method of claim 1 , wherein the atrial fibrillation was a previously unobserved patient condition.

4. The method of claim 3 , further comprising characterizing a range of the record of the interatrial conduction delay and comparing the record with predetermined ranges of the interatrial conduction delay wherein the predetermined ranges are indicative of likely mediating factors of the previously unobserved condition.

5. The method of claim 3 , further comprising determining a variation of the interatrial conduction delay and comparing the determined variation with predetermined variations of the interatrial conduction delay wherein the predetermined variations are indicative of likely mediating factors of the previously unobserved condition.

6. The method of claim 1 , wherein storing the interatrial conduction delay in memory of the device comprises storing a running average of the interatrial conduction delay.

7. The method of claim 1 , wherein the determining interatrial conduction delay at via the device is performed on a regular periodic basis.

8. An implantable cardiac stimulation device comprising:
at least one lead adapted to be implanted within a patient so as to be able to deliver therapeutic stimulation to the patient's heart;
at least one sensor that is adapted to sense signals indicative of electrical activity of the heart of the patient; and
a controller that receives signals indicative of the electrical activity of the heart from the at least one sensor and processes the sensed signals to determine an interatrial conduction delay, wherein the controller selectively induces delivery of therapeutic stimulation to the heart of the patient via the at least one lead, and wherein the controller evaluates a timing parameter related to the interatrial conduction delay to determine if signals corresponding to atrial activity of the heart are indicative that the heart is potentially developing a future dysfunction and wherein the controller records data indicative of the potential future dysfunction upon determining that the data is indicative thereof; and
wherein the at least one parameter of the atrial signals comprises one or more of a P wave duration and an interatrial conduction delay sensed at a left atria (LA).

9. The device of claim 8 , wherein the at least one lead includes a plurality of electrodes wherein at least some of the electrodes can be configured for delivering therapy to the heart of the patient or functioning as the at least one sensor sensing signals indicative of the electrical activity of the heart of the patient.

10. The device of claim 8 , wherein the controller measures length of the P waves and upon determining that the length of the P waves is increasing, records data indicative of the potential future dysfunction.

11. The device of claim 8 , wherein the controller measures the interatrial conduction delays and upon determining that the length of the interatrial conduction delays exceeds a threshold, records data indicative of the potential future dysfunction.

12. The device of claim 8 , wherein the dysfunction comprises one or more of atrial fibrillation, mitral regurgitation (MR) and left ventricle (LV) dysfunctions/remodeling.

13. A implantable cardiac stimulation device comprising:
at least one lead adapted to be implanted within a patient so as to be able to deliver therapeutic stimulation to the patient's heart;
at least one sensor that is adapted to sense signals indicative of atrial activity of the heart of the patient; and
a controller that receives signals indicative of the atrial activity of the heart from the at least one sensor and processes the sensed signals to determine an interatrial conduction delay, wherein the controller selectively induces delivery of therapeutic stimulation to the heart of the patient via the at least one lead, and wherein the controller evaluates a timing parameter related to the interatrial conduction delay from the atrial signals to determine if the signals are indicative that one or both conditions exist of heart failure (HF) worsening or the heart potentially developing a future fibrillation condition and wherein the controller records data indicative of the potential future fibrillation condition upon determining that the data is indicative thereof; and
wherein the at least one timing parameter of the atrial signals comprises one or more of a P wave duration and an interatrial conduction delay sensed at a left atria (LA).

Assignees

• Min Xiaoyi
• Pacesetter Inc

Inventors

• Min Xiaoyi

Classifications

• A61B5/0452

  Human Necessities · mapped topic

• A61N1/3627

  for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy · CPC title

• A61N1/368

  comprising more than one electrode co-operating with different heart regions {(A61N1/3622, A61N1/3627 take precedence)} · CPC title

• A61N1/37 Primary

  Monitoring; Protecting · CPC title

• A61B5/349

  Detecting specific parameters of the electrocardiograph cycle · CPC title