Methods, systems, and devices for pairing vagus nerve stimulation with motor therapy in stroke patients

Patent metadata

Field	Value
Publication number	US-9533152-B2
Application number	US-201414550357-A
Country	US
Kind code	B2
Filing date	Nov 21, 2014
Priority date	Jul 2, 2008
Publication date	Jan 3, 2017
Grant date	Jan 3, 2017

Abstract

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

First claim

What is claimed is:

1. A method, comprising:
treating motor deficits via the actions of:
directing a patient to execute a plurality of therapeutic motions; and
applying a plurality of vagus nerve stimulation pulse trains of electrical stimulation energy to the patient, respective trains of the plurality of trains being in temporal proximity to execution of respective therapeutic motions of the plurality of therapeutic motions exposed to the patient to improve the patient's motor deficits,

wherein the pulse trains are no longer than about 500 milliseconds in duration.

2. The method of claim 1 , further comprising:
detecting a respective beginning of a therapeutic motion of the plurality of therapeutic motions; and
applying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the detected beginning.

3. The method of claim 1 , further comprising:
automatically detecting a respective beginning of a therapeutic motion of the plurality of therapeutic motions; and
automatically applying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the detected beginning.

4. The method of claim 1 , further comprising:
selecting a therapeutic task level for each therapeutic motion.

5. The method of claim 1 , wherein the action of applying a plurality of vagus nerve stimulation pulse trains to the patient entails operating an implanted neurostimulator to deliver pulse trains of electrical stimulation energy to the vagus nerve such that a respective pulse train results in respective directed neuro plasticity lasting no more than about 8 seconds.

6. The method of claim 1 , wherein the action of applying a plurality of vagus nerve stimulation pulse trains to the patient further comprises sensing respective performances of the selected therapeutic motions and applying the pulse trains to the vagus nerve based on the sensed beginnings of the performances.

7. A method, comprising:
treating motor deficits via the actions of:
repetitively exposing a patient to a plurality of therapeutic motions;
pairing a respective vagus nerve stimulation pulse train of electrical;

and stimulation energy with a respective therapeutic motion of the plurality of therapeutic motions, thereby improving the patient's motor deficits,
wherein the method further comprises:
determining that a key portion of a therapeutic motion of the performed therapeutic motions is occurring; and

applying a respective vagus nerve stimulation pulse train of the plurality of pulse trains based on the determined occurrence of the key portion, wherein
the key portion occurs after a beginning of the therapeutic motion.

Assignees

• Microtransponder Inc
• Univ Texas

Inventors

• Kilgard Michael P
• Engineer Navzer
• Pierce David Michael
• Rennaker Robert L

Classifications

• A61N7/00

  Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) · CPC title

• A61N1/361

  Phantom sensations, e.g. tinnitus · CPC title

• A61N1/36053

  adapted for vagal stimulation (A61N1/36114 takes precedence) · CPC title

• A61B5/1124

  Determining motor skills · CPC title

• A61N1/36067 Primary

  Movement disorders, e.g. tremor or Parkinson disease (stimulating motor muscle A61N1/36003) · CPC title