Neurostimulation system and method for automatically adjusting stimulation and reducing energy requirements using evoked action potential

Patent metadata

Field	Value
Publication number	US-9533148-B2
Application number	US-201414187043-A
Country	US
Kind code	B2
Filing date	Feb 21, 2014
Priority date	Feb 22, 2013
Publication date	Jan 3, 2017
Grant date	Jan 3, 2017

Abstract

A neurostimulation system comprising stimulation output circuitry configured for delivering stimulation pulses to target tissue in accordance with a set of stimulation parameters. The neurostimulation system comprises monitoring circuitry configured for continuously measuring action potentials evoked in the target tissue in response to the delivery of the stimulation pulses to the target tissue, memory configured for storing a characteristic of a reference evoked action potential, and at least one processor configured for initiating an automatic mode, in which a characteristic of the measured evoked action potentials is compared to the corresponding characteristic of the reference evoked action potential, and one or more stimulation parameter values in the set of stimulation parameters are adjusted to decrease or increase the energy level of the stimulation pulses, thereby evoking action potentials in the target tissue having substantially the same corresponding characteristic as the reference evoked action potential.

First claim

What is claimed is:

1. A neurostimulation system to automatically optimize power consumption, comprising:
stimulation output circuitry configured for delivering stimulation pulses to target tissue in accordance with a set of stimulation parameters;
monitoring circuitry configured for continuously measuring action potentials evoked in the target tissue in response to the delivery of the stimulation pulses to the target tissue;
memory configured for storing a reference evoked action potential template, the template storing two or more characteristics of a reference evoked action potential that correlates to effective stimulation; and
at least one processor configured for implementing an automatic power consumption optimization process to reduce power consumption and maintain effective stimulation, the automatic power consumption optimization process including comparing two or more characteristics of the measured evoked action potentials to the two or more characteristics of the reference evoked action potential template, and adjusting one or more stimulation parameter values in the set of stimulation parameters to decrease the energy level of the stimulation pulses and evoke action potentials in the target tissue having substantially the same two or more characteristics as the two or more characteristics of the reference evoked action potential template.

2. The neurostimulation system of claim 1 , wherein the set of stimulation parameters includes at least one of a pulse amplitude, a pulse width, a pulse rate, a duty cycle, a burst rate, and an electrode combination.

3. The neurostimulation system of claim 1 , wherein the characteristics of the measured evoked action potentials and the characteristics of the reference evoked action potential include at least one of peak delay, width, amplitude, and waveform morphology.

4. The neurostimulation system of claim 1 , wherein the measured evoked action potentials include one of an evoked compound action potential and an evoked compound muscle action potential.

5. The neurostimulation system of claim 1 , wherein the reference evoked action potential is a therapeutic evoked action potential.

6. The neurostimulation system of claim 1 , wherein the reference evoked action potential is a side-effect evoked action potential.

7. The neurostimulation system of claim 1 , wherein the at least one processor is configured for triggering the automatic mode based on one or more of the following pre-defined conditions:
a. immediately up on measuring evoked action potentials having a characteristic different from the characteristic of the reference evoked action potential;
b. up on measuring evoked action potentials having a characteristic different from the characteristic of the reference action evoked action potential by more than a predetermined tolerance threshold;
c. up on measuring evoked action potentials having a characteristic different from the characteristic of the reference evoked action potential for more than a predetermined time period; and
d. up on measuring evoked action potentials having a characteristic different from the characteristic of the reference evoked action potential for more than a predetermined number of measurements.

8. The neurostimulation system of claim 1 , wherein the at least one processor is configured for halting or resuming the automatic mode based on one or more conditions comprising patient's movement, patient's temperature, patient's blood flow, electrocortigram, electroencephalogram, tissue or transcutaneous oxygen tension, glucose concentration, impedance measurement, chemical species concentration, and whether the patient is asleep or awake.

9. The neurostimulation system of claim 1 , wherein the at least one processor is configured for selecting the stimulation parameter to be adjusted and the step size for the adjustment.

10. The neurostimulation system of claim 1 , wherein the at least one processor is configured for generating an alert upon initiating the automatic stimulation adjustment mode, thereby allowing manual adjustment of the one or more stimulation parameter values.

11. The neurostimulation system of claim 1 , wherein the at least one processor is configured for alternately using two or more of the reference evoked action potentials based on a predefined therapeutic schedule.

12. The neurostimulation system of claim 1 , wherein the at least one processor is further configured to implement an automatic stimulation adjustment mode.

13. The neurostimulation system of claim 12 , wherein the at least one processor is configured for using the comparison between the two or more characteristics of the measured evoked action potentials and the reference evoked action potential to determine whether the stimulation pulses delivered to the target tissue was an over-stimulation or an under-stimulation of the target tissue, and the one or more stimulation parameter values are adjusted to gradually decrease or increase the energy level of the stimulation pulses, respectively, until the measured evoked action potentials have substantially the same two or more characteristics as the two or more characteristics of the reference evoked action potential.

14. The neurostimulation system of claim 1 , wherein the memory is configured for storing a threshold stimulation parameter value and the template, and the at least one processor is configured for:
(a) adjusting at least one stimulation parameter value in the set of stimulation parameters by a step size;
(b) measuring an action potential evoked in the target tissue by actuating the stimulation output circuitry to generate a stimulation pulse in accordance with the at least one stimulation parameter value;
(c) comparing the measured evoked action potential to the template;
(d) replacing the threshold stimulation parameter value in the threshold stimulation parameter set with the at least one adjusted stimulation parameter value when the two or more characteristics of the measured evoked action potential matches the two or more characteristics of the template; and
(e) repeating steps (a)-(d) to identify the most energy efficient set of stimulation parameters capable of generating evoked action potential from the target tissue having substantially the same two or more characteristics as the two or more characteristics of the reference evoked action potential.

15. The neurostimulation system of claim 1 , wherein the stimulation output circuitry, the monitoring circuitry, the at least one processor, and the memory are implemented in a single device.

16. The neurostimulation system of claim 15 , wherein the single device is an implantable electric pulse generator.

17. The neurostimulation system of claim 1 , wherein the stimulation output circuitry, the monitoring circuitry, the at least one processor, and the memory are implemented with a plurality of devices.

Assignees

• Boston Scient Neuromodulation Corp

Inventors

• Carcieri Stephen

Classifications

• A61B5/388

  Nerve conduction study, e.g. detecting action potential of peripheral nerves · CPC title

• A61N1/36185

  Selection of the electrode configuration · CPC title

• A61N1/36175

  Pulse width or duty cycle · CPC title

• A61B5/7246

  using correlation, e.g. template matching or determination of similarity · CPC title

• A61N1/36135

  using physiological parameters · CPC title