Centrifugation system with red blood cell barrier

Patent metadata

Field	Value
Publication number	US-9533089-B2
Application number	US-201214008651-A
Country	US
Kind code	B2
Filing date	Mar 28, 2012
Priority date	Apr 13, 2011
Publication date	Jan 3, 2017
Grant date	Jan 3, 2017

Abstract

Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

First claim

The invention claimed is:

1. A centrifugation system comprising, in combination:
a centrifuge configured to separate blood components from blood by rotation about a rotational axis and comprising
a generally annular low-G wall, and
a generally annular high-G wall located farther from the rotational axis than the low-G wall, wherein
the high-G wall includes a first projection extending toward the low-G wall,
the low-G wall includes a second projection extending toward the high-G wall, and
one end of the first projection is substantially aligned with one end of the second projection along a radius passing through the rotational axis; and

a multiple-stage separation chamber configured to be received in the centrifuge between the low-G and high-G walls, one of the stages of the separation chamber comprising
an inlet port configured for flowing blood into the separation chamber,
a plasma outlet port for flowing a separated blood component substantially comprising plasma out of the separation chamber, and
a red cell outlet port for flowing a separated blood component substantially comprising red blood cells out of the separation chamber wherein, when the separation chamber is received in the centrifuge between the low-G and high-G walls, the first projection is oriented so as to extend into a path of separated blood components flowing toward the plasma outlet port and prevent the separated blood component substantially comprising red blood cells from flowing into the plasma outlet port and the second projection is oriented so as to extend into a path of separated blood components flowing toward the red cell outlet port and prevent the separated blood component substantially comprising plasma from flowing into the red cell outlet port.

2. The centrifugation system of claim 1 , wherein the first projection is oriented at an angle with respect to the rotational axis and the second projection is oriented substantially perpendicular to the rotational axis.

3. The centrifugation system of claim 1 , wherein the second projection is configured and oriented so as to prevent the separated blood component substantially comprising plasma from flowing into the red cell outlet port and redirect the separated blood component substantially comprising plasma to flow into the plasma outlet port.

4. The centrifugation system of claim 1 , wherein
the separation chamber includes an interior seal positioned between the red cell outlet port and the plasma outlet port, and
one end of the second projection is positioned at or adjacent to an end of the interior seal.

5. The centrifugation system of claim 1 , wherein
the separation chamber includes a plurality of interior seals positioned between the red cell outlet port and the inlet and plasma outlet ports, and
the second projection includes ends positioned at or adjacent to said interior seals.

6. The centrifugation system of claim 1 , wherein the ratio of the distance between the second projection and the high-G wall to the distance between the low-G and high-G walls is between approximately 0.01 and approximately 0.99.

7. The centrifugation system of claim 1 , wherein the ratio of the distance between the second projection and the high-G wall to the distance between the low-G and high-G walls is between approximately 0.35 and approximately 0.75.

8. The centrifugation system of claim 1 , wherein the ratio of the distance between the second projection and the high-G wall to the distance between the low-G and high-G walls is between approximately 0.45 and approximately 0.65.

9. A centrifuge configured to separate blood components from blood by rotation about a rotational axis, comprising:
a generally annular low-G wall; and
a generally annular high-G wall located farther from the rotational axis than the low-G wall, wherein
the high-G wall includes a first projection extending toward the low-G wall,
the low-G wall includes a second projection extending toward the high-G wall, and
one end of the first projection is substantially aligned with one end of the second projection along a radius passing through the rotational axis.

10. The centrifuge of claim 9 , wherein the first projection is oriented at an angle with respect to the rotational axis and the second projection is oriented substantially perpendicular to the rotational axis.

11. The centrifuge of claim 9 , wherein the ratio of the distance between the second projection and the high-G wall to the distance between the low-G and high-G walls is between approximately 0.01 and approximately 0.99.

12. The centrifuge of claim 9 , wherein the ratio of the distance between the second projection and the high-G wall to the distance between the low-G and high-G walls is between approximately 0.35 and approximately 0.75.

13. The centrifuge of claim 9 wherein the ratio of the distance between the second projection and the high-G wall to the distance between the low-G and high-G walls is between approximately 0.45 and approximately 0.65.

14. A centrifugation system comprising, in combination:
a centrifuge configured to separate blood components from blood by rotation about a rotational axis and comprising
a generally annular low-G wall, and
a generally annular high-G wall located farther from the rotational axis than the low-G wall, wherein
the high-G wall includes a first projection extending toward the low-G wall,
the low-G wall includes a second projection extending toward the high-G wall, and
one end of the first projection is positioned directly adjacent to one end of the second projection; and

a multiple-stage separation chamber configured to be received in the centrifuge between the low-G and high-G walls, one of the stages of the separation chamber comprising
an inlet port configured for flowing blood into the separation chamber,
a plasma outlet port for flowing a separated blood component substantially comprising plasma out of the separation chamber, and
a red cell outlet port for flowing a separated blood component substantially comprising red blood cells out of the separation chamber wherein, when the separation chamber is received in the centrifuge between the low-G and high-G walls, the first projection is oriented so as to extend into a path of separated blood components flowing toward the plasma outlet port and prevent the separated blood component substantially comprising red blood cells from flowing into the plasma outlet port and the second projection is oriented so as to extend into a path of separated blood components flowing toward the red cell outlet port and prevent the separated blood component substantially comprising plasma from flowing into the red cell outlet port.

15. A centrifugation system comprising, in combination:
a centrifuge configured to separate blood components from blood by rotation about a rotational axis and comprising
a generally annular low-G wall, and
a generally annular high-G wall located farther from the rotational axis than the low-G wall to define a channel therebetween, wherein
the high-G wall includes a first projection extending into the channel toward the low-G wall,
the low-G wall includes a second projection extending into the channel toward the high-G wall, and
one end of the first projection is positioned substantially directly across the channel from one end of the second projection; and

a multiple-stage separation chamber configured to be at least partially received in the channel, one of the stages of the separation chamber comprising
an inlet port configured for flowing blood into the separation chamber,
a plasma outlet port for flowing a s

Assignees

• Min Kyungyoon
• Brown Richard I
• Foley John T
• Case Brian C
• Fenwal Inc

Inventors

• Min Kyungyoon
• Brown Richard I
• Foley John T
• Case Brian C

Classifications

• B04B5/0442

  with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation · CPC title

• B04B2005/045

  having annular separation channels · CPC title

• A61M2205/128

  with incorporated valves · CPC title

• A61M1/3696

  with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation · CPC title

• A61M1/3693 Primary

  using separation based on different densities of components, e.g. centrifuging · CPC title