Radiomic signature of a perivascular region
US-2024404058-A1 · Dec 5, 2024 · US
US9532720B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9532720-B2 |
| Application number | US-201313852132-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 28, 2013 |
| Priority date | Sep 28, 2010 |
| Publication date | Jan 3, 2017 |
| Grant date | Jan 3, 2017 |
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A CPU acquires factor information for a degree of arteriosclerosis, stores a plurality of pseudo blood flow waveforms, generates a waveform estimated as a blood flow waveform by compositing the plurality of pseudo blood flow waveforms based on the factor information, decomposes a pulse waveform into waveforms of an ejected wave and a reflected wave using the pulse waveform and the waveform estimated as the blood flow waveform, and calculates an index of the degree of arteriosclerosis from a relationship between the ejected wave and the reflected wave obtained by decomposing the pulse waveform.
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The invention claimed is: 1. A blood pressure information measurement device for calculating an index of a degree of arteriosclerosis of a measurement subject as blood pressure information, comprising: a detection member comprising a plurality of pressure sensors; a central processing unit that detects a pulse waveform by bringing the detection member into contact with an exterior of a measurement site of the measurement subject, wherein the central processing unit: acquires factor information for the degree of arteriosclerosis; converts the factor information to a coefficient α, the coefficient α being a function of the factor information; stores a first reference waveform and a second reference waveform; generates a waveform estimated as a blood flow waveform by compositing the first reference waveform and the second reference waveform using the coefficient α; decomposes the pulse waveform into waveforms of an ejected wave and a reflected wave using the pulse waveform and the waveform estimated as the blood flow waveform; and calculates the index of the degree of arteriosclerosis from a relationship between the ejected wave and the reflected wave obtained by decomposing the pulse waveform; and a display that displays the index of the degree of arteriosclerosis. 2. The blood pressure information measurement device according to claim 1 , wherein the factor information is at least one from the group consisting of: an augmentation index (A1) value, a difference between times of appearances of the ejected wave and the reflected wave, and a difference between times of peaks of the ejected wave and the reflected wave calculated from the pulse waveform. 3. The blood pressure information measurement device according to claim 1 , wherein the detection member comprises a first air bladder for compressing a measurement site and a second air bladder for compressing a measurement site located on the distal side of the first air bladder, and wherein the central processing unit detects the pulse waveform based on changes in an internal pressure of the first air bladder while blood flow is restricted using the second air bladder. 4. The blood pressure information measurement device according to claim 1 , wherein the factor information comprises an age of the measurement subject. 5. The blood pressure information measurement device according to claim 1 , wherein the central processing unit detects the pulse waveform by detecting a pressure waveform measured in a brachial artery. 6. The blood pressure information measurement device according to claim 1 , wherein the central processing unit detects the pulse waveform by detecting a pressure waveform measured in a radial artery. 7. The blood pressure information measurement device according to claim 1 , wherein the central processing unit detects the pulse waveform by detecting a pressure waveform measured in a carotid artery. 8. A method for calculating an index of a degree of arteriosclerosis of a measurement subject as blood pressure information in a blood pressure information measurement device, comprising: detecting a pulse waveform by bringing a detection member comprising a plurality of pressure sensors into contact with an exterior of a measurement site of the measurement subject; acquiring factor information for the degree of arteriosclerosis; converting the factor information to a coefficient α, the coefficient α being a function of the factor information; storing a first reference waveform and a second reference waveform; generating a waveform estimated as a blood flow waveform by compositing the first reference waveform and the second reference waveform using the coefficient α; decomposing the pulse waveform into waveforms of an ejected wave and a reflected wave using the pulse waveform and the waveform estimated as the blood flow waveform; calculating the index of the degree of arteriosclerosis from a relationship between the ejected wave and the reflected wave obtained by decomposing the pulse waveform; and displaying the index of the degree of arteriosclerosis. 9. The blood pressure information measurement device according to claim 2 , wherein the detection member comprises a first air bladder for compressing a measurement site and a second air bladder for compressing a measurement site located on the distal side of the first air bladder, and wherein the central processing unit detects the pulse waveform based on changes in an internal pressure of the first air bladder while blood flow is restricted using the second air bladder. 10. The blood pressure information measurement device according to claim 2 , wherein the factor information comprises an age of the measurement subject. 11. The blood pressure information measurement device according to claim 2 , wherein the central processing unit detects the pulse waveform by detecting a pressure waveform measured in a brachial artery. 12. The blood pressure information measurement device according to claim 2 , wherein the central processing unit detects the pulse waveform by detecting a pressure waveform measured in a radial artery. 13. The blood pressure information measurement device according to claim 2 , wherein the central processing unit detects the pulse waveform by detecting a pressure waveform measured in a carotid artery.
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