Analytical test strip with capillary sample-receiving chambers separated by a physical barrier island

Patent metadata

Field	Value
Publication number	US-9528958-B2
Application number	US-201514835755-A
Country	US
Kind code	B2
Filing date	Aug 26, 2015
Priority date	Jun 21, 2012
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

An analytical test strip for the determination of an analyte (such as glucose and/or hematocrit) in a bodily fluid sample (such as a whole blood sample) includes a first capillary sample-receiving chamber, a second capillary sample-receiving chamber, and a physical barrier island disposed between the first and second capillary sample-receiving chambers. Moreover, the physical island barrier is disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber is prevented during use of the analytical test strip.

First claim

What is claimed is:

1. A method for determining an analyte in a bodily fluid sample, the method comprising:
providing an analytical test strip, the analytical test strip having:
an electrically insulating substrate layer;
at least one reference electrode and a plurality of working electrodes, all of which are disposed on the electrically insulating substrate layer; and
an enzymatic reagent layer disposed over at least one of, but not all of the working electrodes;

applying a bodily fluid sample to the analytical test strip such that the applied bodily fluid sample fills a first capillary sample-receiving chamber and a second capillary sample-receiving chamber of the analytical test strip and is prevented from flowing between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber by a physical barrier island;
measuring at least a first response of the analytical test strip; and
determining the analyte based on the first measured electrochemical response.

2. The method of claim 1 further including:
measuring a second response of the analytical test strip that is dependent on bodily fluid sample in the second capillary sample-receiving chamber; and
determining a characteristic of the bodily fluid sample based on the second measured response.

3. The method of claim 1 wherein the bodily fluid sample is whole blood.

4. The method of claim 1 wherein the analyte is glucose.

5. The method of claim 1 wherein the applying step includes applying a single bodily fluid sample to a sample application opening of the first capillary sample-receiving chamber a sample application opening of the second capillary sample-receiving chamber, and
wherein the sample application opening of the first capillary sample-receiving chamber and the sample application opening of the second sample-receiving chamber are juxtaposed such that the single bodily fluid sample can be simultaneously applied thereto.

6. The method of claim 5 wherein the physical barrier island extends longitudinally along the first capillary sample-receiving chamber and the second capillary sample-receiving chamber from the sample application opening of the first capillary sample receiving chamber and the sample application opening of the second capillary sample-receiving chamber.

7. The method of claim 6 wherein the physical barrier island is disposed such that:
a first shared sample entry chamber is defined at the first sample application opening of the first capillary sample-receiving chamber and the first sample application opening of the second capillary sample-receiving chamber and
a second shared sample entry chamber is defined at the second sample application opening of the first capillary sample-receiving chamber and the second sample application opening of the second capillary sample-receiving chamber.

8. The method of claim 7 wherein a width of the first shared sample entry chamber is greater than the sum of widths of the first sample application opening of the first capillary sample-receiving chamber and the first sample application opening of the second capillary-sample receiving chamber, and
wherein a width of the second shared sample entry chamber is greater than the sum of widths of the second sample application opening of the first capillary sample-receiving chamber and the second sample application opening of the second capillary-sample receiving chamber.

9. The method of claim 1 wherein the analytical test strip is configured as an electrochemical-based analytical test strip.

Assignees

• Lifescan Scotland Ltd

Inventors

• Whyte Lynsey
• Sloss Scott
• Mccoll David
• Whitehead Neil
• Smith Antony

Classifications

• G01N27/3274

  Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771) · CPC title

• B01L3/502

  with fluid transport, e.g. in multi-compartment structures · CPC title

• B01L2300/0825

  Test strips · CPC title

• G01N33/492 Primary

  Determining multiple analytes · CPC title

• G01N27/3272 Primary

  Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels (optical biosensors G01N33/52) · CPC title