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Base-by-base ratcheting of DNA/RNA in a Y-shaped nanochannel
US9528153B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9528153-B2 |
| Application number | US-201514615910-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 6, 2015 |
| Priority date | Dec 21, 2012 |
| Publication date | Dec 27, 2016 |
| Grant date | Dec 27, 2016 |
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Abstract
Official abstract text for this publication.
A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for sequencing a double strand molecule, the method comprising: driving the double strand molecule into a first Y-channel and a second Y-channel of a membrane by a first voltage pulse, the first Y-channel includes a first stem and first branches, the first branches being connected to the first stem at a first junction; wherein the second Y-channel includes a second stem and second branches formed in the membrane, the second branches being connecte…
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Cross-Sectional Technologies · mapped topic
Operations & Transport · mapped topic
Operations & Transport · mapped topic
Cross-Sectional Technologies · mapped topic
- G01N27/44791Primary
Physics · mapped topic
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Frequently asked questions
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- What does patent US9528153B2 cover?
- A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force require…
- Who is the assignee on this patent?
- IBM
- What technology area does this patent fall under?
- Primary CPC classification G01N27/44791. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Dec 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).