Influenza virus vaccines and uses thereof
US-9051359-B2 · Jun 9, 2015 · US
Humanized monoclonal antibodies and methods of use
US9527924B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9527924-B2 |
| Application number | US-201113700974-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 2, 2011 |
| Priority date | Jun 2, 2010 |
| Publication date | Dec 27, 2016 |
| Grant date | Dec 27, 2016 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Disclosed is a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region germline gene VHI-69. The antibody is derived from Mab G6 and recognizes the same epitope. Moreover, the antibody is used in combination with vaccines to augment an immune response to the antigen.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated humanized monoclonal antibody, wherein said antibody has a humanized heavy chain with three CDRs comprising an amino acid sequence of SEQ ID NO: 5 (GYTFTSYW); SEQ ID NO: 6 (VSPGNSDT); and SEQ ID NO: 7 (TRSRYGNNALDY); and a humanized light chain with three CDRs comprising an amino acid sequence of QGISSNIVW SEQ ID NO: 8 (QGISSNIVW); SEQ ID NO: 9 (HGT); and SEQ ID NO: 10 (VQYSQFPPT), wherein said antibody binds human immunoglobulin heavy chain variable region protein encoded by germline gene VH1-69. 2. A composition comprising an isolated humanized monoclonal antibody, wherein said antibody has a humanized heavy chain with three CDRs comprising an amino acid sequence of SEQ ID NO: 5 (GYTFTSYW); SEQ ID NO: 6 (VSPGNSDT); and SEQ ID NO: 7 (TRSRYGNNALDY); and a humanized light chain with three CDRs comprising an amino acid sequence of QGISSNIVW SEQ ID NO: 8 (QGISSNIVW); SEQ ID NO: 9 (HGT); and SEQ ID NO: 10 (VQYSQFPPT); wherein said antibody binds human immunoglobulin heavy chain variable region protein encoded by germline gene VH1-69; the composition further comprising an antigen; and wherein said antigen comprises the stem region of the hemagglutinin (HA) protein of an influenza virus. 3. The composition of claim 2 , wherein the antibody is a single chain antibody. 4. The composition of claim 2 , wherein the antigen is covalently linked to said antibody.
Assignees
Inventors
Classifications
variable (Fv) region, i.e. VH and/or VL · CPC title
for influenza or rhinoviruses · CPC title
Single chain antibody (scFv) · CPC title
Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title
characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9527924B2 cover?
- Disclosed is a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region germline gene VHI-69. The antibody is derived from Mab G6 and recognizes the same epitope. Moreover, the antibody is used in combination with vaccines to augment an immune response to the antigen.
- Who is the assignee on this patent?
- Marasco Wayne A, Sui Jianhua, Avnir Yuval, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/4216. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).