Packaging solutions

Patent metadata

Field	Value
Publication number	US-9527617-B2
Application number	US-201313917734-A
Country	US
Kind code	B2
Filing date	Jun 14, 2013
Priority date	Oct 23, 2007
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

A packaging system for the storage of an ionic, hydrogel contact lens employs an aqueous packaging solution including a phosphorylcholine polymer. Preferably, the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 8 and is heat sterilized.

First claim

What is claimed is:

1. A method of preparing a package comprising a storable, sterile contact lens, the method comprising:
(a) immersing the contact lens in a solution comprising a phosphorylcholine polymer, wherein the contact lens is an ionic contact lens, wherein the phosphorylcholine polymer comprises a copolymer of a phosphorylcholine (meth)acrylate and an alkyl (meth)acrylate and further wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 8;
(b) packaging the solution and the ionic contact lens in a manner preventing contamination of the lens by microorganisms; and
(c) sterilizing the packaged solution and ionic contact lens.

2. The method of claim 1 , wherein the contact lens is a silicone hydrogel contact lens.

3. The method of claim 1 , wherein the phosphorylcholine polymer comprises a copolymer of 2-methacryloyloxyethyl phosphorylcholine and n-butyl methacrylate.

4. The method of claim 1 , wherein the concentration of the phoshorylcholine polymer is about 0.001 to about 10% w/w.

5. The method of claim 1 , wherein the solution further comprises a non-ionic surfactant.

6. The method of claim 5 , wherein the non-ionic surfactant includes a polyethylene oxide (PEO)/polypropylene oxide (PPO) block copolymer.

7. The method of claim 1 , wherein the solution further comprises a buffering agent.

8. The method of claim 7 , wherein the buffering agent comprises at least one member selected from the group consisting of phosphate; boratecitrate; carbonate; TRIS; bis-tris; Tricine; MOPS; ACES; and an amino acid.

9. The method of claim 1 , wherein the solution further comprises a non-ionic polymer.

10. The method of claim 9 , wherein the non-ionic polymer includes at least one member selected from the group consisting of polyvinylalcohol, a cellulose-derived polymer and poly(N-vinyl pyrrolidinone).

11. The method of claim 1 , including hermetically sealing the contact lens and the contact lens packing solution in the package and heat sterilizing the package contents.

12. The method of claim 1 , wherein the solution does not contain an effective disinfecting amount of a disinfecting agent.

13. The method of claim 1 , wherein the solution does not contain a germicide compound.

Assignees

• Bausch & Lomb

Inventors

• Zhao Fang

Classifications

• C08F230/02

  containing phosphorus · CPC title

• B65B25/008

  packaging of contact lenses · CPC title

• G02B1/043

  Contact lenses · CPC title

• C08F220/282

  and containing two or more oxygen atoms · CPC title

• C08L43/02

  Homopolymers or copolymers of monomers containing phosphorus · CPC title