Nanochanneled device and related methods

Patent metadata

Field	Value
Publication number	US-9526824-B2
Application number	US-201313875871-A
Country	US
Kind code	B2
Filing date	May 2, 2013
Priority date	Nov 14, 2008
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.

First claim

The invention claimed is:

1. A method of fabricating a nanochannel delivery device, the method comprising:
providing first substrate;
forming a plurality of nanochannels on the first substrate;
filling in the plurality of nanochannels with a first sacrificial material;
forming a plurality of inlet microchannels in the first substrate;
filling in the plurality of inlet microchannels with a second sacrificial material;
forming a capping layer that covers the plurality of nanochannels;
forming a plurality of outlet microchannels in the capping layer;
removing the first sacrificial material from the plurality of nanochannels; and
removing the second sacrificial material from the plurality of inlet microchannels.

2. The method of claim 1 , wherein an inlet microchannel of the plurality of inlet microchannels is arranged perpendicular to a primary plane of the first substrate.

3. The method of claim 1 , wherein an outlet microchannel of the plurality of outlet microchannels is arranged perpendicular to a primary plane of the first substrate.

4. The method of claim 1 , wherein an inlet microchannel of the plurality of inlet microchannels is in direct fluid communication with a nanochannel.

5. The method of claim 1 , wherein an outlet microchannel of the plurality of outlet microchannels is in direct fluid communication with a nanochannel.

6. The method of claim 1 , wherein the inlet and outlet microchannels are patterned using a photolithography process.

7. The method of claim 1 , wherein each nanochannel is between approximately one and ten nanometers deep.

8. The method of claim 1 , wherein each nanochannel is between approximately ten and twenty nanometers deep.

9. The method of claim 1 , wherein the first sacrificial material is subsequently removed by selective etching.

10. The method of claim 1 , wherein the first sacrificial material is tungsten.

11. The method of claim 1 , wherein the second sacrificial material is filled into the plurality of inlet microchannels so that the second sacrificial material extends above the top of the plurality of inlet microchannels and is planarized by chemical-mechanical planarization (CMP).

12. The method of claim 1 wherein the capping layer is selected from silicon nitride, silicon oxide, silicon carbonitride, silicon carbide, and silicon.

13. The method of claim 1 , wherein the capping layer comprises multiple depositions of materials comprising tensile and compressive stresses such that the net capping layer stress is tensile.

14. The method of claim 1 , wherein the capping layer is between approximately 0.5 and 1.0 microns thick.

15. The method of claim 1 , wherein the capping layer is between approximately 1.0 and 2.0 microns thick.

16. The method of claim 1 , wherein the capping layer is between approximately 2.0 and 4.0 microns thick.

17. The method of claim 1 , wherein the second sacrificial material is subsequently removed by selective etching.

18. The method of claim 17 , wherein the second sacrificial material is selected from the group consisting of: tungsten, copper, doped glass, and undoped glass.

19. The method of claim 1 , wherein the first substrate comprises a silicon-on-insulator wafer comprising an internal oxide layer.

20. The method of claim 19 , wherein forming the plurality of inlet microchannels comprises etching material from the first substrate, and wherein the etching is terminated at the internal oxide layer.

21. The method of claim 20 , wherein forming a plurality of inlet macrochannels comprises etching material from a back side of the first substrate, and wherein the etching is terminated at the internal oxide layer.

22. The method of claim 21 , further comprising removing of the internal oxide layer after etching material to form the inlet microchannel and inlet macrochannels to open a pathway between the inlet microchannels and inlet macrochannels.

Assignees

• Univ Texas
• Univ Ohio State Res Found

Inventors

• Ferrari Mauro
• Liu Xuewu
• Grattoni Alessandro
• Fine Daniel
• Goodall Randy
• Hosali Sharath
• Medema Ryan
• Hudson Lee

Classifications

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• A61K9/0097 Primary

  Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon · CPC title

• B81B2203/0338

  Channels · CPC title

• B81B2201/058

  Microfluidics not provided for in B81B2201/051 - B81B2201/054 · CPC title

• Y10T137/8593

  Systems · CPC title