Sodium and buffer source cartridges for use in a modular controlled compliant flow path

Patent metadata

Field	Value
Publication number	US-9526822-B2
Application number	US-201313757722-A
Country	US
Kind code	B2
Filing date	Feb 1, 2013
Priority date	Feb 1, 2013
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

Systems and methods for using a sodium chloride source and a buffer source such as sodium bicarbonate in a controlled compliant flow path to generate from water a physiologically compatible fluid having a suitable level of a sodium ion and/or a buffer for use in hemodialysis, hemodiafiltration and hemofiltration. The system has a conditioning flow path that has at least a salination valve or salination pump, and at least one container has at least one solute in excess of the solubility of that solute. At least one of the solutes is a buffer source or sodium chloride. The conditioning flow path is in fluid communication with a controlled compliant flow path. The conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path.

First claim

We claim:

1. A system for generating a physiologically compatible fluid, comprising:
a conditioning flow path having at least a salination valve, and at least one salination pump, and at least one container having at least one solute in excess of the solubility of that solute wherein at least one of the solutes is a buffer source or sodium chloride;
said conditioning flow path in fluid communication with a controlled compliant flow path connected to a dialyzer inlet and a dialyzer outlet and comprising a sorbent cartridge, wherein the conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path, wherein fluid enters the conditioning flow path from the controlled compliant flow path through a conditioning flow path inlet; and exits the conditioning flow path to the controlled compliant flow path through a conditioning flow path outlet; and wherein the conditioning flow path inlet is positioned in the controlled compliant flow path downstream from the conditioning flow path outlet.

2. The system of claim 1 , further comprising an extracorporeal flow path fluidly connected to the dialyzer, wherein the controlled compliant flow path modifies water into any one of a solution for priming an extracorporeal circuit, rinsing or flushing the dialyzer and blood flow conduits, a physiologically compatible solution for contacting blood, a physiologically compatible solution for bolus infusion to a subject, and a solution for blood rinse back to a subject.

3. The system of claim 1 , wherein selectively metering in and metering out fluid from the controlled compliant flow path generates a physiologically compatible level of a sodium ion and/or a buffer from the at least one container in the conditioning flow path.

4. The system of claim 1 , further comprising a sodium chloride container and a buffer source container.

5. The system of claim 4 , wherein the conduits and containers of the conditioning flow path are controlled compliant.

6. The system of claim 4 , wherein the sodium chloride and the buffer source are dry compositions, the dry compositions being hydrated by circulating a fluid through the conditioning flow path.

7. The system of claim 1 , wherein a means for selectively metering fluid into and out of the controlled compliant flow path is a fluid balance control pump in fluid communication with the controlled compliant flow path and a fluid reservoir.

8. The system of claim 7 , wherein a means for selectively metering fluid into and out of the controlled compliant flow path is any one of a control pump, a water pump, a salination pump, an acid concentrate pump, a replacement fluid pump, and combinations thereof.

9. The system of claim 1 , wherein the controlled compliant flow path has at least one pump or valve in fluid communication with both a conduit of the controlled compliant flow path and a container; and
a pump in fluid communication with a conduit of the controlled compliant flow path and a water source.

10. The system of claim 4 , further comprising at least one pump or valve in fluid communication with a conduit of the controlled compliant flow path and at least a buffer source or a sodium source, a pump in fluid communication with a conduit of the controlled compliant flow path and a water source.

11. The system of claim 4 , wherein fluid passing through the sodium chloride container increases the sodium chloride concentration of the fluid and fluid passing through the buffer source container increases the buffer concentration of the fluid.

12. The system of claim 4 , wherein the sodium chloride container, the buffer source container and the salination valve are configured into a consumables cartridge.

13. The system of claim 4 , wherein the sodium chloride and the buffer source are contained in separate compartments of a common container or cartridge.

14. The system of claim 13 , wherein the sodium compartment and the buffer source compartment share a common fluid inlet port or a common fluid outlet port.

15. The system of claim 4 , wherein a container is disposable.

16. The system of claim 4 , wherein a container is re-usable and refilled or replenished with sodium chloride or a buffer source.

17. The system of claim 4 , wherein a sodium chloride container or a buffer source container are configured together with any of an extracorporeal circuit, a dialyzer, a degassing module, a cation concentrate reservoir, a control reservoir, a sorbent container, a cleaning and/or disinfection concentrate, or an ammonia sensing module into a therapy cassette.

18. The system of claim 4 , wherein the salination valve is located downstream from the sodium chloride container and the buffer source container and the salination pump is located upstream from the sodium chloride container and the buffer source container.

19. The system of claim 4 , wherein the salination valve is located upstream from the sodium chloride container and the buffer source container and the salination pump is located downstream from the sodium chloride container and the buffer source container.

20. The system of claim 4 , wherein fluid flow through the sodium chloride container and the buffer source container can occur concurrently.

21. The system of claim 4 , wherein the controlled compliant flow path is fluidly connected to a source selected from the group consisting of a potable water source, a tap water source, a bottled water source, a purified water source and combinations thereof, a physiologically compatible solution source, a dialysate source, a filtrate source, or a replacement fluid source; and wherein a portion of the fluid entering a container is water selected from any one of potable water, tap water, bottled water, purified water and combinations thereof, a physiologically compatible solution, a dialysate, a filtrate, or a replacement fluid.

22. The system of claim 4 , further comprising a sorbent system, and wherein a portion of the fluid entering a container is water that has been purified through the sorbent system.

23. The system of claim 4 , wherein the sodium chloride container contains a first dry composition and the buffer source container contains a second dry composition, the first and second dry compositions are hydrated during circulation of fluid through the conditioning flow path and the quantity of the dry compositions provided are in excess of the quantities required for operation wherein a portion of the dry compositions remains undissolved in the sodium chloride container and the buffer source container, the sodium chloride container and the buffer source container being operable such that a saturated solution exits the sodium chloride container and/or the buffer source container.

24. The system of claim 23 , wherein a container has at least one fluid inlet port and at least one fluid outlet port, and filtering media at the inlet port and outlet port to prevent at least a portion of undissolved sodium chloride or undissolved buffer source from exiting the container.

25. The system of claim 4 , wherein a consumables cartridge has a sodium chloride container, a buffer source container and a salination valve for controlling flow of fluid diverted from a conduit of the controlled compliant flow path through the sodium chloride container and the buffer source container.

26. The system of claim 4 , wherein the salination valve controls the amount of a fluid flowing through the c

Assignees

• Medtronic Inc

Inventors

• Meyer Thomas E
• Lura David B
• Pudil Bryant J
• Gerber Martin T

Classifications

• A61M1/1605

  Physical characteristics of the dialysate fluid · CPC title

• A61M1/3609

  Physical characteristics of the blood, e.g. haematocrit, urea · CPC title

• A61M1/1666

  by dissolving solids · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title