Compositions and methods for targeted delivery to cells
US-2024390271-A1 · Nov 28, 2024 · US
Thermostabilization of proteins
US9526786B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9526786-B2 |
| Application number | US-201414166619-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 28, 2014 |
| Priority date | Jul 10, 2007 |
| Publication date | Dec 27, 2016 |
| Grant date | Dec 27, 2016 |
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Abstract
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Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating a cocaine-induced condition, the method comprising: administering to a mammalian subject in need thereof an effective amount of a composition comprising a cocaine esterase (CocE) polypeptide comprising an amino acid sequence at least 85% identical to SEQ ID NO: 1 having esterase activity; and at least one thermostabilization compound selected from…
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Classifications
Human Necessities · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
- A61K47/22Primary
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9526786B2 cover?
- Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-des…
- Who is the assignee on this patent?
- Landry Donald W, Woods James H, Sunahara Roger K, and 7 more
- What technology area does this patent fall under?
- Primary CPC classification A61K47/22. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Dec 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).