Method for suppressing surgical site infection and column to be used for the method

Patent metadata

Field	Value
Publication number	US-9526735-B2
Application number	US-201414200733-A
Country	US
Kind code	B2
Filing date	Mar 7, 2014
Priority date	Jul 22, 2004
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject. The present invention also provides a column for blood circulation which is filled with a carrier having affinity for leukocytes comprising neutrophils, which is used for suppressing a surgical site infection during or within 24 hours after surgical operation on a digestive system organ.

First claim

The invention claimed is:

1. A blood processing method for a surgical subject, wherein leukocytes comprising neutrophils are removed from the blood of a surgical subject during or within 24 hours after surgical operation on a digestive system organ.

2. The blood processing method for a surgical subject according to claim 1 , wherein the number of leukocytes that comprise neutrophils and are removed is 6×10 7 or more and 1×10 9 or less per kg of the body weight of the surgical subject.

3. The blood processing method for a surgical subject according to claim 1 , wherein the digestive system organ is selected from among the esophagus, stomach, small intestine, large intestine, rectum, colon, appendix, liver, pancreas, and gallbladder.

4. The blood processing method for a surgical subject according to claim 1 , wherein the surgical subject is a patient who has inflammatory bowel disease or cancer of a digestive system organ.

5. The blood processing method for a surgical subject according to claim 1 , wherein leukocytes comprising neutrophils are removed during or within 2 hours after the surgical operation.

6. The blood processing method for a surgical subject according to claim 1 , wherein leukocytes comprising neutrophils are removed using either a method that comprises removing leukocytes comprising neutrophils with the use of a specific gravity difference between erythrocytes and leukocytes by means of centrifuge or a method that comprises removing leukocytes comprising neutrophils with the use of a carrier having affinity for leukocytes.

7. The blood processing method for a surgical subject according to claim 1 , wherein the carrier having affinity for leukocytes is selected from among a cellulose derivative containing cellulose acetate, polyester, polyolefin, poly(vinylidene fluoride), polyamide, polyimide, polyurethane, polysulfone, and polyacrylonitrile.

8. The blood processing method for a surgical subject according to claim 1 , wherein leukocytes comprising neutrophils are removed during or within 6 hours after the surgical operation.

Assignees

• Asahi Kasei Medical Co Ltd

Inventors

• Kusunoki Masato
• Miki Chikao
• Yoshiyama Shigeyuki

Classifications

• A61K31/546 Primary

  containing further heterocyclic rings, e.g. cephalothin · CPC title

• A61M2202/0439

  White blood cells; Leucocytes · CPC title

• A61K35/14

  Blood; Artificial blood (perfluorocarbons A61K31/02; umbilical cord blood A61K35/51; haemoglobin A61K38/42) · CPC title

• A61M1/3679

  by absorption (A61M1/3675 takes precedence) · CPC title

• A61K31/43

  Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula [IMAGE cpc-sch-A61K-0952.gif], e.g. penicillins, penems · CPC title