Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
US9526731B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9526731-B2 |
| Application number | US-201414563126-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 8, 2014 |
| Priority date | Apr 20, 2006 |
| Publication date | Dec 27, 2016 |
| Grant date | Dec 27, 2016 |
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A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.
Opening claim text (preview).
We claim: 1. A method of treating C-KIT related malignant myeloma, said method comprising inhibiting the kinase activity of C-KIT by administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising
containing three or more hetero rings · CPC title
containing three or more hetero rings · CPC title
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone · CPC title
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
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