Compositions for the treatment of peripheral ulcers of various origins

Patent metadata

Field	Value
Publication number	US-9526716-B2
Application number	US-201514935036-A
Country	US
Kind code	B2
Filing date	Nov 6, 2015
Priority date	Sep 16, 2011
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use.

First claim

The invention claimed is:

1. A method of treating peripheral ulcers, radiodermitis induced by radiotherapy and chemotherapy, ulcerated haemorrhoids, proctitis and vulvovaginitis in a subject in need thereof, said method comprising:
administering an effective amount of a composition comprising:
a) bisulphite adducts of anthocyanosides from Vaccinium myrtillus,
b) a lipophilic extract of Echinacea sp., to a subject in need thereof; and
treating said subject.

2. The method according to claim 1 , wherein the ulcers are diabetic ulcers, ulcers of the limbs due to venous stasis, ulcers due to radiation or mechanical or thermal injuries and bedsores.

3. The method according to claim 1 , wherein the composition further comprises anthocyanosides from Vaccinium myrtillus.

4. The method according to claim 3 , wherein the ulcers are diabetic ulcers, ulcers of the limbs due to venous stasis, ulcers due to radiation or mechanical or thermal injuries and bedsores.

Assignees

• Indena Spa

Inventors

• Bombardelli Ezio

Classifications

• A61P9/14

  Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P31/02

  Local antiseptics · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title