Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury

Patent metadata

Field	Value
Publication number	US-9526706-B1
Application number	US-201514740410-A
Country	US
Kind code	B1
Filing date	Jun 16, 2015
Priority date	Jun 16, 2015
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

The present invention relates to a method of using trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

First claim

What is claimed is:

1. A method of treating acute inflammatory condition of the pancreas and associated systemic complications by administering to a subject in need thereof a composition comprising an effective amount of a stilbenoid type compound of formula (1),

or a derivative or variant of said stilbenoid type compound, wherein R 1 , R 2 and R 3 in said stilbenoid type compound are each independently a hydrogen or an alkyl group, any said all group being a straight chain alkyl moiety having 1, 2, 3, 4, 5 or 6 carbon atoms.

2. The method of claim 1 wherein any said alkyl group is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, pentyl, and hexyl.

3. The method according to claim 1 wherein the stilbenoid derivative is trans-3,5,4′-trihydroxybibenzyl which is a compound of formula (2):

or its derivative or variants.

4. The method according to claim 1 wherein the subject is a human or an animal.

5. The method according to claim 1 wherein the composition is administered orally.

6. The method according to claim 1 wherein the acute inflammatory condition of the pancreas comprises all forms of acute pancreatitis and associated systemic complications comprising pulmonary injury.

7. The method according to claim 1 wherein said composition is administered at no less than 20 mg/kg to said subject for no less than 3 times a day.

8. The method according to claim 1 wherein said composition is administered at no less than 3.24 mg/kg to said subject for no less than 3 times a day.

9. A method for preparing a compound of molecular formula C 14 H 14 O 3 and of formula (2),

which is a stilbenoid derivative having a chemical name of trans-3,5,4′-trihydroxybibenzyl, through a hydrogenation of trans-resveratrol, comprising the steps of:
stirring a solution of trans-resveratrol in anhydrous ethyl hydroxide at room temperature under 5 atm H 2 pressure in the presence of 10% Pd/C catalyst for 8 hours;
filtering off the catalyst from the stirred solution;
evaporating the filtrate in vacuum to produce a residue; and
eluting the residue using a silica gel chromatographic separation with petroleum ether and ethyl acetate in a ratio of 1:1 to produce dihydro-resveratrol.

Assignees

• Univ Hong Kong Baptist Univ

Inventors

• Bian Zhaoxiang
• Tsang Siu Wai
• Zhang Hongjie
• Lu Aiping
• Chan Albert Sun-Chi

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/18

  for pancreatic disorders, e.g. pancreatic enzymes · CPC title

• C07C39/15

  with all hydroxy groups on non-condensed rings {, e.g. phenylphenol} · CPC title

• C07C37/003 Primary

  by hydrogenation of an unsaturated part · CPC title

• A61K31/09 Primary

  having two or more such linkages · CPC title