Quantitatively characterizing disease morphology with cell orientation entropy
US-9183350-B2 · Nov 10, 2015 · US
US9524552B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9524552-B2 |
| Application number | US-201213564675-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 1, 2012 |
| Priority date | Aug 3, 2011 |
| Publication date | Dec 20, 2016 |
| Grant date | Dec 20, 2016 |
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A method for preparing an image simulating the anatomy of a small subject test animal, and an apparatus for producing said image and an anatomical atlas for co-registering therewith, comprising the generation of two or more non-tomographic images of the test animals is described. Examples of the non-tomographic imaging modalities and the images generated include, but are not limited to one or more x-ray sources and resultant of x-ray projections, photographic cameras and resulting digital or optical images and surface scanners and resultant surface scans. The subject animal is positioned at a focal point in a carrier in an imaging enclosure. A combination of one or more of the non-tomographic images taken from different angles within the enclosure are combined and through an iterative process co-registered with the previously generated digital atlas of the anatomy of the same or similar test animals.
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We claim: 1. A method for preparing an image simulating the anatomy of a small subject test animal comprising the use of two or more non-tomographic imaging modalities, said non-tomographic imaging modalities incorporated in a single imaging enclosure including, but not limited to one or more x-ray sources and resultant x-ray projections, photographic cameras and resulting digital or optical images and surface scanners and resultant surface scans, said process comprising: placing…
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