Crosslinked fibers and method of making same using UV radiation

Patent metadata

Field	Value
Publication number	US-9523159-B2
Application number	US-201013202388-A
Country	US
Kind code	B2
Filing date	Feb 22, 2010
Priority date	Feb 21, 2009
Publication date	Dec 20, 2016
Grant date	Dec 20, 2016

Abstract

Cross-linked fibers include first and second precursors, each possessing a core and at least one functional group known to have click reactivity when exposed to UV radiation. Mixtures of the first and second precursors are extruded to produce a filament and irradiated with UV light during the extrusion process.

First claim

What is claimed is:

1. A process of forming a cross-linked filament for a surgical device comprising:
mixing first and second precursors, each of the first and second precursors possessing a polyol core and functionalized with at least one functional group having click reactivity when exposed to UV radiation, wherein the at least one functional group of the first precursor is a thiol group and the at least one functional group of the second precursor is an alkene group; and
extruding the first and second precursors through an extrusion unit to produce a filament,
exposing the first and second precursors to UV radiation during the extruding process.

2. The process of claim 1 , wherein the polyol core of the first precursor is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

3. The process of claim 1 , wherein the polyol core of the second precursor is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

4. The process according to claim 1 , wherein exposing the first and second precursors to UV radiation occurs while in a molten state.

5. The process according to claim 1 , wherein exposing the first and second precursors to UV radiation occurs after forming the filament.

6. The process according to claim 1 , wherein exposing the first and second precursors to UV radiation further comprises passing the filament through a quench bath irradiated with a UV light.

7. The process according to claim 1 , wherein the polyol core of the first precursor comprises a poly(ethylene glycol) with a molecular weight from about 200 g/mol to about 10000 g/mol.

8. The process according to claim 1 , wherein the polyol core of the first precursor comprises a poly(ethylene glycol) with a molecular weight from about 400 g/mol to about 900 g/mol.

9. The process according to claim 1 , wherein the polyol core of the second precursor comprises a poly(ethylene glycol) with a molecular weight from about 200 g/mol to about 10000 g/mol.

10. The process according to claim 1 , wherein the polyol core of the second precursor comprises a poly(ethylene glycol) with a molecular weight from about 400 g/mol to about 900 g/mol.

11. The process according to claim 1 , wherein the polyol core of the first precursor and the polyol core of the second precursor are different.

12. The process according to claim 1 , wherein the at least one functional group of the first precursor and the at least one functional group of the second precursor are present in a ratio of about 1:2 to 1:1.

Assignees

• Hadba Ahmad Robert
• Ladet Sébastien
• Covidien Lp
• Sofradim Production

Inventors

• Hadba Ahmad Robert
• Ladet Sébastien

Classifications

• D10B2509/00

  Medical; Hygiene · CPC title

• D10B2331/30

  polycondensation products not covered by indexing codes D10B2331/02 - D10B2331/14 · CPC title

• D01F6/86

  from polyetheresters · CPC title

• C08G75/045

  from mercapto compounds and unsaturated compounds · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title