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Thiazolidinedione derivatives, preparation thereof and use thereof in cancer treatment
US9522909B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9522909-B2 |
| Application number | US-201314374030-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 25, 2013 |
| Priority date | Jan 26, 2012 |
| Publication date | Dec 20, 2016 |
| Grant date | Dec 20, 2016 |
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Abstract
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The present invention relates to thiazolidinedione derivatives, to the processes for preparing same and to the therapeutic use thereof for preventing or treating cancer, and more specifically breast cancer. These compounds are of formula (I) and exhibit, at a concentration of 100 μM, a hepatocyte viability preferably greater than 60%, preferably greater than 80% and more preferentially greater than 85%.
First claim
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The invention claimed is: 1. A compound of formula (I) having, at a concentration of 100 μM, hepatocyte viability greater than 60% corresponding to the percentage of surviving suspended human hepatocytes after 90 minutes of incubation and, wherein R 3 is a group:…
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Chemistry & Metallurgy · mapped topic
- C07D417/14Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9522909B2 cover?
- The present invention relates to thiazolidinedione derivatives, to the processes for preparing same and to the therapeutic use thereof for preventing or treating cancer, and more specifically breast cancer. These compounds are of formula (I) and exhibit, at a concentration of 100 μM, a hepatocyte viability preferably greater than 60%, preferably greater than 80% and more preferentially greater …
- Who is the assignee on this patent?
- Boisbrun Michel, Chapleur Yves, Bordessa Andrea, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C07D417/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 20 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).