Controlled release nanoparticulate matter delivery system

Patent metadata

Field	Value
Publication number	US-9522241-B2
Application number	US-201313849060-A
Country	US
Kind code	B2
Filing date	Mar 22, 2013
Priority date	Mar 22, 2012
Publication date	Dec 20, 2016
Grant date	Dec 20, 2016

Abstract

A controlled release nanoparticulate matter delivery system includes a plurality of thermoresponsive modules containing a respective nanoparticulate matter. Each thermoresponsive module is selectively operable in at least one of a heating mode that releases the nanoparticulate matter and a cooling mode that inhibits release of the nanoparticulate matter. A control module is in electrical communication with the plurality of thermoresponsive modules. The control module is configured to determine a temperature of each thermoresponsive module and to select the at least one heating mode and cooling mode based on the temperature. The heating and cooling mode may be selected in response to a desired dosing profile and/or a biometric condition.

First claim

What is claimed is:

1. A thermoresponsive module to release a nanoparticulate matter, comprising:
control module configured to generate a first voltage having a first polarity that induces current to flow in a first direction and to generated second voltage having a second polarity that induces current to flow in a second direction opposite the first direction in response to a second voltage polarity;
a thermoelectric device in signal communication with the control module and including a variable temperature surface, the thermoelectric device selectively operable in at least one of a heating mode to actively heat the variable temperature surface when the current flows in the first direction, and a cooling mode to cool the variable temperature surface when the current flows in the second direction; and
a hydrocomposite carrier to deliver the nanoparticulate matter therefrom based on the temperature of the variable temperature surface.

2. The thermoresponsive module of claim 1 , wherein the hydrocomposite carrier includes a thermoresponsive polymer that contains the nanoparticulate matter and that is configured to selectively release the nanoparticulate matter based on a temperature generated by thermoelectric device.

3. The thermoresponsive module of claim 2 , wherein the thermoresponsive polymer retains the nanoparticulate matter therein when existing at a first temperature range and releases the nanoparticulate matter therefrom when existing at a temperature exceeding the first temperature range.

4. The thermoresponsive module of claim 3 , wherein the thermoresponsive polymer is formed from Poly[N-isopropylacrylamide-co-acrylamide] (PNIPAM-AAm).

5. The thermoresponsive module of claim 4 , further comprising a thermal sensor configured to output a voltage signal indicating a temperature at the thermoelectric device.

6. The thermoresponsive module of claim 1 , wherein the thermoelectric device is a Peltier device.

Assignees

• Raytheon Co
• Univ Texas
• Univ Texas

Inventors

• Blanco Letia M
• Godfrey Kyle C
• Grace Christopher A
• Alberts Christopher B
• Patin Andrew E
• Shiakolas Panayiotis S
• Aswath Pranesh B

Classifications

• A61K9/0004

  Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas · CPC title

• A61M2205/36

  related to heating or cooling · CPC title

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61K9/7092

  Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs · CPC title

• A61M2205/3673

  thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors · CPC title