Methods of treating hepatitis

Patent metadata

Field	Value
Publication number	US-9522163-B2
Application number	US-201314094140-A
Country	US
Kind code	B2
Filing date	Dec 2, 2013
Priority date	May 17, 2002
Publication date	Dec 20, 2016
Grant date	Dec 20, 2016

Abstract

The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.

First claim

What is claimed is:

1. A method of treating hepatitis in a patient at risk of acute liver failure, comprising:
identifying a patient diagnosed as suffering from hepatitis that is not a post-operative result of liver transplantation, and who is at risk of acute liver failure; and
administering to the patient by inhalation a gaseous pharmaceutical composition comprising from 100 ppm to 800 ppm of carbon monoxide for up to six hours per day to reduce hepatocyte death in the patient.

2. The method of claim 1 , wherein the patient is infected with a virus selected from the group consisting of: hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus, hepatitis E virus, and hepatitis G virus.

3. The method of claim 1 , wherein the patient is an alcoholic.

4. The method of claim 1 , further comprising administering antiviral agents to the patient.

5. The method of claim 1 , wherein the hepatitis is caused by exposure to a hepatotoxic agent.

6. The method of claim 1 , wherein administering the gaseous composition comprising carbon monoxide comprises:
providing a vessel containing a pressurized gas comprising carbon monoxide gas;
releasing the pressurized gas from the vessel, to form an atmosphere comprising carbon monoxide gas; and
exposing the patient to the atmosphere.

7. The method of claim 1 , further comprising withholding or reducing administration of hepatitis-inducing drugs.

8. The method of claim 1 , further comprising administering corticosteroids to the patient.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education
• Univ Yale

Inventors

• Otterbein Leo E
• Choi Augustine M K
• Zuckerbraun Brian Scott

Classifications

• A61P31/12

  Antivirals · CPC title

• A61P31/14

  for RNA viruses · CPC title

• A61K33/00 Primary

  Medicinal preparations containing inorganic active ingredients · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61P1/16

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title