Oral care compositions

Patent metadata

Field	Value
Publication number	US-9522103-B2
Application number	US-201114365690-A
Country	US
Kind code	B2
Filing date	Dec 20, 2011
Priority date	Dec 20, 2011
Publication date	Dec 20, 2016
Grant date	Dec 20, 2016

Abstract

Disclosed herein are compositions comprising a fluoride ion source, a poly(propylene oxide)/poly(ethylene oxide) copolymer, and optionally a sparingly soluble acid; and methods of using and of making the same.

First claim

The invention claimed is:

1. An oral care composition comprising:
a fluoride ion source;
fumaric acid in an amount effective to enhance delivery of fluoride to the enamel; and
a poly(propylene oxide)/poly(ethylene oxide) copolymer in an amount effective to provide greater than 90% recovery of soluble fluoride ions after 3 months at 40° C.,

wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer is present in an amount of from about 0.1% to about 10%, by weight, of the composition and
wherein the fumaric acid is present in an amount of from about 0.01 to about 0.5%, by weight, of the composition.

2. The composition of claim 1 , wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer has a molecular weight of from about 8,000 to about 18,000 g/mol, and an ethylene oxide content of from about 30 to about 90%, by weight of the copolymer.

3. The composition of claim 1 , wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer has a molecular weight of from about 12,000 to about 15,000 g/mol, and an ethylene oxide content of from about 70 to about 80%, by weight of the copolymer.

4. The composition of claim 1 , wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer is selected from: Poloxamer 237; Poloxamer 217; Poloxamer 184; Poloxamer 185; Poloxamer 188; Poloxamer 338; Poloxamer 407; and a combination of two or more thereof.

5. The composition of claim 2 , wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer is selected from Poloxamer 237; Poloxamer 188; Poloxamer 338; Poloxamer 407; and a combination of two or more thereof.

6. The composition of claim 1 , wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer is selected from: Poloxamer 338; Poloxamer 407; and a combination of two or more thereof.

7. The composition of claim 1 , wherein the fumaric acid is present in an amount of from about 0.01 to about 0.25%, of the total composition weight.

8. The composition of claim 1 , wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, titanium fluoride, hexafluorosulfate, silver diamine fluoride, indium 10 fluoride, zinc fluoride, and a combination of two or more thereof.

9. The composition of claim 1 , wherein the fluoride ion source is present in an amount of about 0.01 wt. % to about 2 wt. % of the total composition weight.

10. The composition of claim 1 , wherein the pH is about 6.5 to about 7.5 in undiluted form, and wherein the pH of the composition is lowered from about 0.6 to about 2 pH units, during use.

11. The composition of claim 1 , further comprising a calcium ion source.

12. The composition of claim 11 , wherein the calcium ion source is tricalcium phosphate hydroxyapatite, dicalcium phosphate dihydrate, calcium pyrophosphate, amorphous calcium phosphate, or mixtures thereof present in an amount of about 0.01 to about 1% of the total composition weight.

13. The composition of claim 1 , in a form selected from: a mouthrinse, a toothpaste, a tooth gel, a tooth powder, a non-abrasive gel, an oral care mousse, a foam, mouth spray, a lozenge, a tablet, a dental implement, and a pet care product.

14. A method of enhancing delivery of fluoride to tooth enamel comprising applying an effective amount of the composition according to claim 1 to the oral cavity of a subject in need thereof.

15. A method of enhancing protection of teeth against caries and cavities and increasing resistance to acid demineralization comprising administering to the oral cavity, of a subject in need thereof, a composition according to claim 1 .

16. A composition according to claim 1 for use in enhancing protection of teeth against caries and cavities and increasing resistance to acid demineralization.

17. A composition according to claim 1 , wherein the poly(propylene oxide)/poly(ethylene oxide) copolymer is present in an amount of from about 2.5% to about 5%, by weight, of the composition.

Assignees

• Morgan Andre
• Joziak Marilou
• Prencipe Michael
• Colgate Palmolive Co

Inventors

• Morgan Andre
• Joziak Marilou
• Prencipe Michael

Classifications

• A61K8/368

  with carboxyl groups directly bound to carbon atoms of aromatic rings · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2800/54

  Polymers characterized by specific structures/properties · CPC title

• A61K8/49

  containing heterocyclic compounds · CPC title

• A61K8/362

  Polycarboxylic acids · CPC title