Signal activated RNA interference
US-9029524-B2 · May 12, 2015 · US
Signal activated RNA interference
US9518263B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9518263-B2 |
| Application number | US-201514691256-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 20, 2015 |
| Priority date | Dec 10, 2007 |
| Publication date | Dec 13, 2016 |
| Grant date | Dec 13, 2016 |
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Abstract
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The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.
First claim
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We claim: 1. A signal-activatable polynucleotide construct for enzyme-assisted molecular delivery, the construct comprising: a targeting domain and a sensor domain covalently bound to the targeting domain, the sensor domain comprising: a signal detection region complementary to at least one signal polynucleotide, a first chimeric sequence comprising at least one RNA region, a second chimeric sequence comprising a DNA region complementary to an RNA region of the at least one…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N15/113Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9518263B2 cover?
- The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that character…
- Who is the assignee on this patent?
- California Inst Of Techn
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 13 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).