Pyrazolopyridines and pyrazolopyrimidines

Patent metadata

Field	Value
Publication number	US-9518052-B2
Application number	US-201514710631-A
Country	US
Kind code	B2
Filing date	May 13, 2015
Priority date	May 14, 2014
Publication date	Dec 13, 2016
Grant date	Dec 13, 2016

Abstract

A compound having the structure:

or a pharmaceutically acceptable salt or solvate thereof, wherein A and A′ are C or N, where C may be substituted by halo or C 1 -C 6 alkyl; R and R 0 are selected from the group consisting of H, C 1 -C 6 alkyl, —(CH 2 ) n —W, etc., where W is 5- or 6-membered heteroaryl or heterocyclic containing N, S and/or O atoms, —NR″SO 2 —R′, etc., where R′ and R″ are C 1 -C 6 alkyl, etc.; wherein each alkyl, etc., may be substituted; or, R and R 0 and the N atom to which they are bonded together to form a monocyclic or bicyclic heterocyclic ring, etc.; R 1 is H, halo or cyano; R 2 and R 2′ are H, C 1 -C 6 alkyl, etc.; X is a bond, etc.; R 3 is H, C 1 -C 4 alkyl, etc.; Y is a bond, —(CH 2 ) m —, etc. The invention also relates to compositions and uses in the treatment of various diseases.

First claim

The invention claimed is:

1. A compound having the structure:

or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein:
A, A″ and A′″ are independently C or N, where C may be unsubstituted or substituted by halo or C 1 -C 6 alkyl;
R 1 is H, cyano or halo;…

Assignees

• Pfizer

Inventors

• Coe Jotham Wadsworth
• Dehnhardt Christoph Martin
• Jones Peter
• Sabnis Yogesh Anil
• Strohbach Joseph Walter
• Wakenhut Florian Michel
• Whitlock Gavin Alistair

Classifications

• A61P35/00

  Human Necessities · mapped topic

• A61P7/02

  Human Necessities · mapped topic

• A61P9/00

  Human Necessities · mapped topic

• A61P9/04

  Human Necessities · mapped topic

• A61P3/10

  Human Necessities · mapped topic