Implantable cardiac therapy device

Patent metadata

Field	Value
Publication number	US-9517348-B2
Application number	US-201213597262-A
Country	US
Kind code	B2
Filing date	Aug 29, 2012
Priority date	Sep 14, 2011
Publication date	Dec 13, 2016
Grant date	Dec 13, 2016

Abstract

An implantable cardiac therapy device having a heart assist pump, a stimulation unit, and a control unit. The heart assist pump is designed to be connected to a ventricle of a heart and an associated artery, and is designed to pump blood from a particular ventricle into an associated artery, thereby supporting the particular ventricle. The stimulation unit is designed to electrically stimulate a heart contraction, and the control unit is designed to control the heart assist pump and the stimulation unit in such a way that the stimulation unit induces synchronized motions of cardiac contraction while the heart assist pump operates in a ventricle-supporting manner.

First claim

What is claimed is:

1. An implantable cardiac therapy device comprising
a heart assist pump which is configured to connect to a particular ventricle of a heart and an associated artery, and configured to pump blood from the particular ventricle into the associated artery, to support or relieve the particular ventricle;
a stimulation unit configured to electrically stimulate a heart contraction; and,
a control unit which is connected to the heart assist pump and the stimulation unit and configured to control the heart assist pump and the stimulation unit in a coordinated manner such that
the stimulation unit induces synchronized motions of cardiac contraction while the heart assist pump operates in a ventricle-supporting manner;

said stimulation unit comprises at least one stimulation unit and said control unit, in combination with the at least one stimulation unit or a plurality of stimulation units, is configured to control stimulation therapy to synchronize a ventricle not connected to the heart assist pump with pumping function of the heart assist pump to achieve synchronous ventricular function,
said control unit is configured to utilize a delay between a point in time of an intended delivery of a right-ventricular stimulation pulse and an action of the heart assist pump coupled with a left ventricle of the heart, said action of the heart assist pump coupled with a left ventricle of the heart comprises left-ventricular pumping activity, and,
said delay time comprises two delay times and said control unit is further configured to detect a course of right-ventricular contraction and contraction dynamics and to dynamically adapt the two delay times to resynchronization needs.

2. The implantable cardiac therapy device according to claim 1 , wherein the control unit is configured, in combination with the stimulation unit, to deliver stimulation pulses to both ventricles of the heart in a coordinated manner.

3. The implantable cardiac therapy device according to claim 1 , wherein said stimulation unit comprises at least one stimulation unit and wherein the control unit, in combination with the at least one stimulation unit, is configured to control and induce delivery of stimulation pulses to achieve biventricular stimulation therapy.

4. The implantable cardiac therapy device according to claim 1 , wherein said stimulation unit comprises at least one stimulation unit and wherein the control unit, in combination with the at least one stimulation unit, is configured to control and induce delivery of stimulation pulses to an atrium and one or two ventricles.

5. The implantable cardiac therapy device according to claim 1 , further comprising stimulation electrodes, wherein the stimulation unit is connected to the stimulation electrodes, some or all of which are an integral component of the heart assist pump or a portion thereof.

6. The implantable cardiac therapy device according to claim 1 , further comprising a pressure sensor as part of the heart assist pump wherein the pressure sensor is configured to detect a mitral valve closure, and wherein the control unit is configured to control therapy times as a function of the mitral valve closure that was detected.

7. The implantable cardiac therapy device according to claim 1 , further comprising an impedance sensor and wherein said stimulation unit comprises at least one stimulation unit and wherein the control unit is configured to function as a contraction sequence control unit that is configured to control the at least one stimulation unit with respect to points in time at which stimulation pulses are delivered, and if applicable, is configured to perform closed-loop stimulation or CLS which is based on an evaluation of right-ventricular contraction dynamics which are detected via one or more intracardiac impedance measurements obtained from said impedance sensor.

8. The implantable cardiac therapy device according to claim 1 , wherein the control unit is configured to function as a contraction sequence control unit, that is configured to automatically monitor stimulation success.

9. The implantable cardiac therapy device according to claim 8 , wherein the control unit is configured to automatically detect a stimulation threshold of a ventricle, and to automatically set a particular intensity of a stimulation pulse based on said stimulation success.

10. The implantable cardiac therapy device according to claim 1 , wherein said heart assist pump is configured as a left-ventricular heart assist pump and further comprising sensing and stimulation units connected to the control unit including a sensor connected to the control unit that is configured to detect right-ventricular contractility or contraction velocity, and wherein the control unit is configured to lower systolic discharge via the heart assist pump and, optionally, lower stimulation frequency if the right-ventricular contractility decreases, in order to prevent right-ventricular volume overload.

11. The implantable cardiac therapy device according to claim 1 , further comprising an impedance sensor configured to detect intracardiac impedance, and a cardiac stimulator, or at least one stimulation unit which is connect to and controlled by the control unit, wherein the control unit is configured to control delivery of stimulation pulses as a function of an output signal of the impedance sensor, which indicates intracardiac impedance.

12. The implantable cardiac therapy device according to claim 11 , wherein the control unit is configured to control delivery of stimulation pulses based on the output signal of the impedance sensor that indicates cardiac contractility to increase contractility as needed.

13. The implantable cardiac therapy device according to claim 1 , further comprising a defibrillation unit which is configured to generate and deliver defibrillation pulses, and which is connected to and controlled by the control unit.

14. The implantable cardiac therapy device according to claim 1 , wherein said two delay times are started simultaneously.

15. A method for treating cardiac insufficiency with an implantable cardiac therapy device comprising:
pumping blood from a particular ventricle into an associated artery of a heart, to support or relieve the particular ventricle with a heart assist pump which is configured to connect to the particular ventricle of the heart and the associated artery;
stimulating a heart contraction electrically with a stimulation unit,
wherein said stimulation unit comprises at least one stimulation unit;

controlling the heart assist pump and the stimulation unit in a coordinated manner with a control unit which is connected to the heart assist pump and the stimulation unit and wherein said controlling further comprises
inducing synchronized motions of cardiac contraction with the stimulation unit while operating the heart assist pump in a ventricle-supporting manner;

controlling stimulation therapy to synchronize a ventricle not connected to the heart assist pump with pumping function of the heart assist pump to achieve synchronous ventricular function with the control unit in combination with the at least one stimulation unit or a plurality of stimulation units;
utilizing a delay between a point in time of an intended delivery of a right-ventricular stimulation pulse and an action of the heart assist pump coupled with a left ventricle of the heart with the control unit, wherein the action of the heart assist pump coupled with a left ventricle of the heart comprises left-ventricular pumping activity, and,
wherein said delay time comprises two delay times and wherein the control

Assignees

• Doerr Thomas
• Weiss Ingo
• Biotronik Se & Co Kg

Inventors

• Doerr Thomas
• Weiss Ingo

Classifications

• A61N1/3684

  for stimulating the heart at multiple sites of the ventricle or the atrium · CPC title

• A61N1/3712

  Auto-capture, i.e. automatic adjustment of the stimulation threshold · CPC title

• A61N1/36521

  the parameter being derived from measurement of an electrical impedance · CPC title

• A61N1/36843

  Bi-ventricular stimulation · CPC title

• A61N1/36564

  controlled by blood pressure · CPC title