Coated titanium dioxide to reduce the whitening effect on skin

Patent metadata

Field	Value
Publication number	US-9517190-B2
Application number	US-201514661487-A
Country	US
Kind code	B2
Filing date	Mar 18, 2015
Priority date	Mar 18, 2014
Publication date	Dec 13, 2016
Grant date	Dec 13, 2016

Abstract

The present invention relates to coated titanium dioxide particles, wherein at least one coating layer comprises an ester made from a mixture of fatty alcohol and C6 to C12 aliphatic acids as coating material.

First claim

What is claimed is:

1. Coated titanium dioxide particles, wherein at least one coating layer comprises an ester made from a mixture of C 12 to C 30 fatty alcohols and C 6 to C 12 aliphatic acids as coating material.

2. The particles of claim 1 , wherein the coating material is at least a C 16 -C 18 nonanoate derivative or mixture thereof.

3. The particles of claim 1 , wherein the coating material comprises cetearyl nonoate and/or cetearyl isononoate.

4. The particles of claim 1 , wherein the titanium dioxide particles comprise one or more additional coating layer, whereby the coating material is selected from the group consisting of silica (SiO2), aluminium hydroxide (Al 2 (OH) 3 , aluminium oxide (Al 2 O 3 ), sodium hexametaphosphate (Na(PO 3 ) 6 ), sodium metaphosphate (Na(PO 3 )n, aluminium stearate, stearic acid, lauric acid, dimethicone, or mixtures thereof.

5. The particles of claim 1 , wherein the loading capacity of the coating material comprising a mixture of fatty acid esters, on the particles is in the range from 5 to 25%, referring to the total weight of a particle.

6. The particles of claim 4 , wherein the loading capacity of the coating material is in the range of 5 to 15 wt.%, referring to the total weight of a particle.

7. The particles of claim 1 , wherein at least one dimension of individual crystals making up agglomerates of the particles is <100 nm.

8. A cosmetic and/or pharmaceutical preparation comprising the coated titanium dioxide particles of claim 1 .

9. The preparation of claim 8 , wherein the amount of the titanium dioxide particles is in the range of 0.5 to 25%, referring to the total preparation.

10. The preparation of claim 8 , further comprising at least one UV filter in an amount from 0.1 to 65.0%, referring to the total amount of all UV filters, referring to the total amount of the preparation.

11. The preparation of claim 10 , wherein the UV filters are selected from the group consisting of:
Avobenzone,
Homosalate,
Octisalate,
Octocrylene,
2-Ethylhexyl p-methoxycinnamate,
Isoamyl p-methoxycinnamate,
3-(4′-methylbenzylidene)-d,l-camphor,
2,4,6-trianilino(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine,
Tris-Biphenyl Triazine,
Diethylhexyl Butamido Triazone,
Benzylidenemalonate-polysiloxane,
2-Ethylhexyl 4-dimethylaminobenzoate,
Drometrizole Trisiloxane,
Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine,
2,2′-Methylenebis(6-(2H-benztriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)-phenol),
Diethylamino Hydroxybenzoyl Hexyl Benzoate,
Disodium Phenyl-dibenzimidazole Tetrasulphonate and its salts,
Phenyibenzimidazole- sulphonic Acid and its salts,
Terephthalyiidene Dicamphor Sulfonic Acid and its salts,
Benzophenone-4 and its salts,
Benzophenone-3,
Menthyl anthranilate,
Padimate O,
Zinc oxide,
and their mixtures.

12. The preparation of claim 8 , further comprising auxiliaries and additives selected from surfactants, oil bodies, co-emulsifiers, superfatting agents, pearlising waxes, consistency factors, polymers, silicone compounds, stabilizers, antidandruff agents, film formers, swelling agents, hydrotropes, preservatives, solubilizers, complexing agents, reducing agents, alkalising agents, perfume oils, dyes, fats, moisturizers, antioxidants, antiperspirants, insect repellants, self-tanning agents, tyrosine inhibitors (depigmenting agents), bodying agents, antimicrobial agents, antifoams, aqueous and non-aqueous plant extracts and the like as additional auxiliaries and additives.

13. The preparation of claim 8 , having a sun protection factor of at least 2.

14. The preparation of claim 8 , having a UVA protection factor of at least 2, measured by the Colipa Method for in vitro determination of UVA protection, 2011.

15. The preparation of claim 8 , which is a dermatological preparation selected from the group consisting of creams, hydrogels, hydrodispersion gels, oil gels, lotions, balsams.

Assignees

• Symrise Ag

Inventors

• Johncock William
• Peters Simone
• Issleib Martina
• Claus Jürgen

Classifications

• A61P17/16

  Emollients or protectives, e.g. against radiation · CPC title

• A61P17/18

  Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00) · CPC title

• A61K8/19

  containing inorganic ingredients · CPC title

• A61K8/29 Primary

  Titanium; Compounds thereof · CPC title

• C09C1/3669

  Treatment with low-molecular organic compounds · CPC title