Anti-migration micropatterned stent coating

Patent metadata

Field	Value
Publication number	US-9517122-B2
Application number	US-201414210979-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 15, 2013
Publication date	Dec 13, 2016
Grant date	Dec 13, 2016

Abstract

An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

First claim

The invention claimed is:

1. An endoprosthesis having an expanded state and an unexpanded state, the endoprosthesis comprising:
a stent, wherein the stent has a first end, a second end, and a longitudinal axis extending therebetween, the stent having an inner surface extending from the first end to the second end and defining a lumen, an outer surface extending from the first end to the second end, and a thickness defined between the inner surface and the outer surface; and
a stent end covering disposed at the first end of the stent and extending longitudinally beyond the first end of the stent and then doubling back into the lumen of the stent, the stent end covering comprising:
a polymeric coating comprising a base and a plurality of protrusions, the base comprising a first major surface facing radially inwardly, the base further comprising a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern, wherein the micropattern of protrusions of the stent end covering extends longitudinally beyond the first end of the stent.

2. The endoprosthesis of claim 1 , wherein the stent end covering is adhered to the outer surface of the stent.

3. The endoprosthesis of claim 1 , wherein the stent end covering is adhered to the inner surface of the stent.

4. The endoprosthesis of claim 1 , wherein the stent end covering extends circumferentially and entirely around the first end of the stent.

5. The endoprosthesis of claim 1 , wherein the stent end covering extends circumferentially and partially around the first end of the stent.

6. The endoprosthesis of claim 1 , wherein the stent end covering extends longitudinally from a location between the first and second ends to a location that is not between the first and second ends.

7. The endoprosthesis of claim 1 , wherein at least a first portion of the stent end covering has a radial thickness greater than the thickness of the stent at the first end of the stent.

8. The endoprosthesis of claim 7 , wherein at least a second portion of the stent end covering has a radial thickness less than the radial thickness of the first portion of the stent end covering.

9. The endoprosthesis of claim 1 , wherein the stent end covering is a first stent end covering, and the endoprosthesis further comprises:
a second stent end covering disposed at the second end of the stent.

10. The endoprosthesis of claim 9 , wherein:
the first stent end covering has a first end and a second end, the first end of the first stent end covering doubling back into the stent lumen forming a cushion around the first end of the stent;
the second stent end covering has a first end and a second end, the first end of the second stent end covering located beyond the second end of the stent; and
the second end of the first end covering is spaced apart from the second end of the second end covering.

11. An endoprosthesis, comprising:
a stent, wherein the stent has a first end, a second end, and a longitudinal axis extending therebetween, the stent having an inner surface extending from the first end to the second end and defining a lumen, an outer surface extending from the first end to the second end, and a thickness defined between the inner surface and the outer surface; and
a stent end covering disposed at the first end of the stent, the stent end covering comprising:
a first end and a second end;
an inner surface and an outer surface, the inner surface facing radially inward, and
a plurality of protrusions extending outwardly from the outer surface and
wherein the protrusions are arranged in a micropattern; and
wherein the first end of the stent end covering extends longitudinally beyond the first end of the stent and then doubles back into the lumen, the first end of the stent end covering is located a first distance from the second end of the stent and the second end of the stent end covering is located a second distance from the second end of the stent, the second distance being less than the first distance; and
wherein the second end of the stent end covering is located intermediate the first and second ends of the stent.

12. The endoprosthesis of claim 11 , wherein the first end of the stent end covering that doubles back into the lumen forms a cushion around the first end of the stent.

13. The endoprosthesis of claim 12 , wherein the micropattern of protrusions of the stent end covering extends longitudinally beyond the first end of the stent.

14. The endoprosthesis of claim 11 , wherein the stent end covering is a first stent end covering, and the endoprosthesis further comprises:
a second stent end covering disposed at the second end of the stent.

15. The endoprosthesis of claim 14 , wherein:
the second stent end covering has a first end and a second end, wherein the first end of the second stent end covering is located a first distance from the first end of the stent and the second end of the second stent end covering is located a second distance from the first end of the stent, the second distance being less than the first distance; and
the second end of the first end covering is spaced apart from the second end of the second end covering.

16. The endoprosthesis of claim 15 , wherein a medial portion of the stent is exposed between the first stent end covering and the second stent end covering.

17. An implantable medical device, comprising:
a stent having a first end, a second end, and a longitudinal axis extending therebetween the stent having an inner surface extending from the first end to the second end and defining a lumen, and an outer surface extending from the first end to the second end;
a first stent covering section disposed around a circumference of the stent, the first stent covering section comprising:
a first end and a second end,
an inner wall surface facing radially inwardly and an outer wall surface facing radially outwardly, and
a plurality of protrusions extend outwardly from the outer wall surface,

wherein the protrusions are arranged in a micropattern,
a second stent covering section disposed around the circumference of the stent, the second stent covering section comprising:
a first end and a second end,
an inner wall surface facing radially inwardly and an outer wall surface facing radially outwardly, and
a plurality of protrusions extending outwardly from the outer wall surface,
wherein the protrusions are arranged in a micropattern;

wherein the first stent covering section is longitudinally spaced away from the second stent covering section, wherein the first end of the first stent covering section extends longitudinally beyond the first end of the stent and then doubles back into the stent lumen.

18. The implantable medical device of claim 17 , wherein a medial portion of the stent is exposed between the first stent covering section and the second stent covering section.

19. The implantable medical device of claim 18 , wherein the first stent covering section is disposed at the first end of the stent and the second stent covering section is disposed at the second end of the stent.

20. The implantable medical device of claim 17 , wherein:
the first end of the first stent covering section that doubles back into the stent lumen forms a cushion around the stent terminal end point;
the first end of the second stent covering section is located beyond the second end of the stent; and
the second end of

Assignees

• Boston Scient Scimed Inc

Inventors

• Firstenberg Laura Elizabeth
• Fleury Sean P

Classifications

• A61F2002/072

  Encapsulated stents, e.g. wire or whole stent embedded in lining · CPC title

• A61F2/848 Primary

  having means for fixation to the vessel wall, e.g. barbs · CPC title

• A61F2220/0008

  Fixation appliances for connecting prostheses to the body · CPC title

• A61F2/04

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title

• A61F2/06

  Blood vessels · CPC title