Antimicrobial alcohol foam compositions and methods of preparation

Patent metadata

Field	Value
Publication number	US-9516877-B2
Application number	US-201314387989-A
Country	US
Kind code	B2
Filing date	Mar 15, 2013
Priority date	Mar 30, 2012
Publication date	Dec 13, 2016
Grant date	Dec 13, 2016

Abstract

A method for preparing an antimicrobial alcoholic foam composition by combining two or more pre-mix compositions. A first pre-mix composition is primarily alcoholic comprises an alcohol, an acidic component, and a waxy component. A second pre-mix composition is primarily aqueous comprises water and a carbonate. An antimicrobial alcoholic foam composition that does not require added air or aerosol propellant is also provided.

First claim

What is claimed is:

1. A method of preparing an antimicrobial alcoholic foam composition, the method comprising the steps of:
providing a dispenser having a first reservoir containing a first liquid pre-mix that is an aqueous pre-mix, a second reservoir containing a second liquid pre-mix that is an alcoholic pre-mix;
dispensing an aliquot of said aqueous pre-mix, wherein said aqueous pre-mix comprises a carbonate and water;
dispensing an aliquot of said alcoholic pre-mix, wherein said alcoholic pre-mix comprises at least 50 wt. % of a C 1-6 alcohol, based upon the total weight of the alcoholic pre-mix, a waxy component, and an acidic component;
commingling said aliquot of said aqueous pre-mix and said aliquot of said alcoholic pre-mix, whereupon said aliquots of said aqueous pre-mix and said alcoholic pre-mix chemically react and generate an antimicrobial alcoholic foam.

2. The method of claim 1 where the acidic component is selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, phosphonic acid, boric acid, sulfuric acid, adipic acid, benzene 1,3,5 tricarboxylic acid, chlorosuccinic acid, choline chloride, cis-aconitic acid, citramalic acid, citric acid, cyclobutane 1,1,3,3 tetracarboxylic acid, cyclohexane 1,2,4,5 tetracarboxylic acid, cyclopentane 1,2,3,4 tetracarboxylic acid, diglycolic acid, fumaric acid, glutamic acid, glutaric acid, glyoxylic acid, isocitric acid, ketomalonic acid, lactic acid, maleic acid, malic acid, malonic acid, nitrilotriacetic acid, oxalacetic acid, oxalic acid, phytic acid, p-toluenesulfonic acid, salicylic acid, succinic acid, tartaric acid, tartronic acid, tetrahydrofuran 2,3,4,5 tetracarboxylic acid, tricarballylic acid, versene acids, 3-hydroxyglutaric acid, 2-hydroxypropane 1,3 dicarboxylic acid, glyceric acid, furan 2,5 dicarboxylic acid, 3,4-dihydroxyfuran-2,5 dicarboxylic acid, 3,4-dihydroxytetrahydrofuran-2,5-dicarboxylic acid, 2-oxo-glutaric acid, dl-glyceric acid, and 2,5 furandicarboxylic acid, tartaric acid, malic acid, gluconic acid, fumaric acid, ascorbic acid, citric acid, isocitric acid, lactic acid, tartronic acid, oxalic acid, salicylic acid, malonic acid, potassium bitartrate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate, disodium pyrophosphate, calcium lactate, calcium sulfate, calcium phosphate, sodium aluminum phosphate, sodium aluminum sulfate, monosodium phosphate and disodium pyrophosphate, and mixtures thereof.

3. The method of claim 1 wherein the acidic component is selected from the group consisting of citric acid, lactic acid, malic acid, tartaric acid, salicylic acid, oxalic acid, and mixtures thereof.

4. The method of claim 1 wherein the acidic component is citric acid.

5. The method of claim 1 wherein the amount of acidic component is at least 0.02 equivalent weights of acid per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

6. The method of claim 1 wherein the amount of acidic component is from 0.5 to about 2 times the number of equivalent weights of carbonate present in the aqueous pre-mix.

7. The method of claim 1 wherein the amount of acidic component is the stoichiometric amount of acid required to produce at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

8. The method of claim 1 wherein the carbonate is selected from the group consisting of sodium carbonate, potassium carbonate, lithium carbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, ammonium bicarbonate, and mixtures thereof.

9. The method of claim 1 wherein the carbonate is potassium bicarbonate.

10. The method of claim 1 wherein the amount of carbonate is an effective amount.

11. The method of claim 1 wherein the amount of carbonate is the stoichiometric amount of carbonate required to yield at least 0.02 moles of carbon dioxide per 100 g of combined aqueous pre-mix and alcoholic pre-mix.

12. The method of claim 1 wherein the aqueous pre-mix is a saturated solution with respect to the carbonate.

13. The method of claim 1 wherein the waxy component is selected from the group consisting of carnauba wax, ouricury wax, Japan wax, cork fiber wax, sugarcane wax, paraffin waxes, lignite waxes, microcrystalline waxes, lanolin wax, ozokerite, polyethylene wax, silicone waxes, plant waxes, C 8-24 fatty alcohols, C 8-24 fatty acids, glycerides that are solid at room temperature, blends of a C 8-24 fatty alcohol with an ethoxylated C 8-24 fatty alcohol, blends of a C 8-24 fatty alcohol and a non-ionic surfactant, and mixtures thereof, with the proviso that the wax is at least sparingly soluble in a lower alcohol at standard temperature and pressure.

14. The method of claim 1 wherein the waxy component is an emulsifying wax.

15. The method of claim 1 wherein the waxy component is present in an amount of at least 0.2 wt. %, based upon the total weight of the alcoholic pre-mix.

16. The method of claim 1 wherein the waxy component is present in an amount of at least 0.1 wt. %, based upon the total weight of the combined alcoholic pre-mix and aqueous pre-mix.

17. The method of claim 1 wherein the aqueous pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, polaxamer, polyethoxylated siloxane polymer, or a mixture thereof.

18. The method of claim 1 wherein the alcoholic pre-mix further comprises an emulsifier selected from the group consisting of polysorbate, poloxamer, polyethoxylated siloxane polymer, or a mixture thereof.

19. The method of claim 18 wherein the emulsifier is a poloxamer.

20. The method of claim 1 wherein the aqueous pre-mix may further comprise up to about 49 wt. % C 1-6 alcohol.

21. The method of claim 1 wherein the foam expands upon the reaction of the acid and the carbonate to a final volume that is 1.5 to 5 times the combined liquid volume of the aqueous pre-mix and the alcoholic pre-mix.

22. The method of claim 1 wherein the foam is stable for at least 1 minute at room temperature and pressure.

23. A method of preparing a non-aerosol antimicrobial alcoholic foam composition, the method comprising the steps of:
providing a dispenser having a first reservoir containing a first liquid pre-mix that is an aqueous pre-mix, a second reservoir containing a second liquid pre-mix that is an alcoholic pre-mix;
dispensing an aliquot of said aqueous pre-mix, wherein said aqueous pre-mix comprises a carbonate and water;
dispensing an aliquot of said alcoholic pre-mix, wherein said alcoholic pre-mix comprises at least 50 wt. % of a C 1-6 alcohol, based upon the total weight of the alcoholic pre-mix, a waxy component, and an acidic component;
commingling said aliquot of said aqueous pre-mix and said aliquot of said alcoholic pre-mix, whereupon said aliquots of said aqueous pre-mix and said alcoholic pre-mix chemically react and generate an antimicrobial alcoholic foam;
wherein the foam expands upon the reaction of the acid and the carbonate to a final volume that is 1.5 to 5 times the combined liquid volume of the aqueous pre-mix and the alcoholic pre-mix.

24. The method of claim 23 , where the acidic component is selected from the group consisting of hydrochloric acid, nitric acid, phosphoric acid, phosphonic acid, boric acid, sulfuric acid, adipic acid, benzene 1,3,5 tricarboxylic acid, chlorosuccinic acid, choline chloride, cis-aconitic acid, citramalic acid, citric acid, cyclobutane 1,1,3,3 tetracarb

Assignees

• Gojo Ind Inc

Inventors

• Cohen Mitchell Jared
• Eberts Iii James Harvey
• Hillman Evan David

Classifications

• A61P31/02

  Local antiseptics · CPC title

• A61Q17/005

  Antimicrobial preparations · CPC title

• A01N59/00

  Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61K8/19

  containing inorganic ingredients · CPC title