Method for risk stratification in stable coronary artery disease

Patent metadata

Field	Value
Publication number	US-9513301-B2
Application number	US-201514939595-A
Country	US
Kind code	B2
Filing date	Nov 12, 2015
Priority date	Aug 3, 2007
Publication date	Dec 6, 2016
Grant date	Dec 6, 2016

Abstract

An in vitro method for the risk stratification of patients with stable arteriosclerosis, especially stable coronary artery disease, is disclosed wherein the concentration of procalcitonin is determined in the circulation of such patients using a highly sensitive PCT assay, and wherein within the range of PCT concentrations in the typical normal range of healthy individuals cutoff values are defined which distinguish groups of individual patients with stable arteriosclerosis in accordance with personal cardiac risk, and patients are allotted to one of said risk groups on the basis of their individual PCT concentrations.

First claim

The invention claimed is:

1. A method for assessing the risk of future cardiovascular events in an individual with stable coronary artery disease (CAD), the method comprising:
(a) contacting a blood, plasma, or serum sample from the individual having stable coronary disease (CAD) with antibodies of a dual antibody assay for the determination of procalcitonin (PCT) with a functional assay sensitivity of <0.007 ng/ml PCT to determine the level of procalcitonin (PCT) in said plasma or serum sample from the individual; and
(b) identifying the individual as being at highest risk of experiencing future adverse cardiovascular events when the PCT level is equal to or greater than 0.05 ng/ml.

2. The method of claim 1 , wherein in conjunction with the determination of PCT at least one further analyte useful for cardiovascular prognosis is determined, said at least one analyte being selected from the group consisting of natriuretic peptides, adrenomedullin, endothelins, vasopressin, CRP, neopterin, myeloperoxidase, troponin, GDF-15, cystatin-C and their precursors, their prohormones and associated prohormone fragments.

Assignees

• Brahms Gmbh

Inventors

• Bergmann Andreas
• Struck Joachim
• Morgenthaler Nils G
• Papassotiriou Jana
• Blankenberg Stefan
• Lackner Karl
• Rupprecht Hans
• Bickel Christoph

Classifications

• G01N2800/324

  Coronary artery diseases, e.g. angina pectoris, myocardial infarction · CPC title

• G01N2800/50

  Determining the risk of developing a disease · CPC title

• G01N33/53

  Immunoassay; Biospecific binding assay; Materials therefor · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• G01N2333/585

  Calcitonins · CPC title