Method and apparatus for optical imaging via spectral encoding

Patent metadata

Field	Value
Publication number	US-9513276-B2
Application number	US-201414311916-A
Country	US
Kind code	B2
Filing date	Jun 23, 2014
Priority date	Sep 29, 2005
Publication date	Dec 6, 2016
Grant date	Dec 6, 2016

Abstract

Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.

First claim

What is claimed is:

1. An apparatus comprising:
at least one imaging first arrangement configured to provide first data associated with a first signal at least one of received from or provided to at least one region of at least one structure, wherein the region has a linear dimension that is not more than about 10 microns;
at least one second arrangement which includes a coherence ranging system that is configured to provide second data associated with (i) a second signal at least one of received from or forwarded to the at least one structure, and (ii) a third signal at least one of received from or provided to a reference, wherein the first and second data are provided substantially simultaneously by the first and second arrangements; and
at least one computer third arrangement configured to generate further data based on the first and second data.

2. The apparatus according to claim 1 , wherein the at least one computer third arrangement is further configured to generate at least one of a two-dimensional image or a three-dimensional image based on the further data.

3. The apparatus according to claim 1 , wherein the first and second data are associated with approximately the same location on the at least one structure.

4. The apparatus according to claim 1 , wherein the at least imaging first arrangement and the coherence ranging system are provided in at least one of a probe or a single enclosure.

5. The apparatus of claim 4 , further comprising a mechanical transducer positioning arrangement configured to position at least one of the probe or the single enclosure at a particular location relative to the structure based on at least one of the first data or the second data.

6. The apparatus according to claim 1 , wherein the at least imaging first arrangement and the coherence ranging system include at least one common component.

7. The apparatus according to claim 6 , wherein the at least one common component is provided in a wavelength swept-source arrangement.

8. The apparatus according to claim 1 , wherein the at least one imaging first arrangement is configured to obtain confocal microscopy information.

9. The apparatus according to claim 8 , wherein the confocal microscopy information is reflectance confocal microscopy information.

10. The apparatus according to claim 1 , wherein the at least one imaging first arrangement is configured to obtain spectral encoding microscopy information.

11. The apparatus according to claim 1 , wherein the coherence ranging system is configured to obtain optical coherence tomography information.

12. The apparatus according to claim 1 , wherein the coherence ranging system is configured to obtain optical coherence tomography information associated with a signal provided by a source arrangement having a plurality of wavelengths, and further comprising a plurality of detectors configured to detect a spectral interference between the second and third signals based on the wavelengths.

13. The apparatus according to claim 1 , wherein the coherence ranging system is configured to obtain optical coherence tomography information associated with a signal provided by a source arrangement whose wavelength varies over time.

14. The apparatus according to claim 1 , wherein the at least one computer third arrangement is further configured to control at least one of the at least one imaging first arrangement or the coherence ranging system based on previously-obtained at least one of the first data or the second data.

15. The apparatus according to claim 1 , wherein the at least one computer third arrangement is further configured to generate an image based on the first and second data.

16. The apparatus according to claim 1 , wherein the at least one computer third arrangement is further configured to generate at least one first image based on the first data and at least one second image based on the second data, wherein the first and second images are associated with one another based on the first and second data.

17. The apparatus according to claim 1 , further comprising a lens focusing arrangement configured to control at least one of a focal length or a focal position associated with at least one of the at least one imaging first arrangement or the coherence ranging system based on at least one of the first data or the second data.

18. The apparatus according to claim 1 , wherein the first data is associated with at least one first location within the at least one region, and the second data is associated with at least one second location of the at least one structure.

19. The apparatus according to claim 1 , wherein the at least one structure is an anatomical structure.

20. The apparatus according to claim 1 , further comprising at least one lens focusing arrangement configured to control at least one of a focal length or a focal position associated with at least one of the at least one imaging first arrangement or the coherence ranging system when at least one of the first data or the second data are being acquired.

21. A method for obtaining particular data associated with at least one structure, comprising:
with an imaging system, obtaining first data associated with a first signal at least one of received from or provided to at least one region of the at least one structure, wherein the region has a linear dimension that is not more than about 10 microns;
with a coherence ranging system, retrieving second data associated with (i) a second signal at least one of received from or provided to the at least one structure, and (ii) a third signal at least one of received from or provided to a reference, wherein the first and second data are provided substantially simultaneously; and
using a computer system, generating the particular data based on the first and second data.

Assignees

• Massachusetts Gen Hospital

Inventors

• Tearney Guillermo J
• Bouma Brett E
• Yelin Dvir

Classifications

• G01B9/02087

  Combining two or more images of the same region · CPC title

• G01N21/4795

  spatially resolved investigating of object in scattering medium (in vivo A61B) · CPC title

• G02B23/243

  Objectives for endoscopes · CPC title

• G01B9/02064

  by particular adjustment of coherence gate, i.e. adjusting position of zero path difference in low coherence interferometry · CPC title

• A61B5/0066

  Optical coherence imaging · CPC title