Gas chromatograph-ion mobility spectrometer system

Patent metadata

Field	Value
Publication number	US-9513266-B2
Application number	US-201414577653-A
Country	US
Kind code	B2
Filing date	Dec 19, 2014
Priority date	Dec 27, 2013
Publication date	Dec 6, 2016
Grant date	Dec 6, 2016

Abstract

A GC-IMS system is disclosed. The system includes a sample transfer device. The sample transfer device connects the gas chromatograph to the reaction region and, the sample from the gas chromatograph is transferred to the reaction region by the sample transfer device. With the GC-IMS system, generation of sample molecular ion fragments can be avoided so that the spectrum is easily identified; moreover, the application field of the GC-IMS system is extended to a range of analysis of organic macromolecule samples which have a high polarity, are difficult to volatilize, and are thermally instable. On the other hand, the GC-IMS system overcomes the defect of ion destruction due to neutralization reaction among positive and negative ions so as to evade the detection.

First claim

What is claimed is:

1. A GC-IMS system, comprising:
a gas chromatograph,
an IMS comprising: an ionization region for ionizing a gas to generate ions, and a reaction region which is adjacent to and different from the ionization region, is disposed downstream of the ionization region in an ion drift direction, and is configured for combining the ions with a sample,
a sample transfer device which connects the gas chromatograph to the reaction region and is configured to transfer the sample from the gas chromatograph to the reaction region directly by bypassing the ionization region, and
a sweeping gas inlet which is formed in the IMS and is configured to flow a sweeping gas with no sample through the ionization region into the reaction region of the IMS, wherein the ions generated in the ionization region are moved to the reaction region under a sweeping action of the sweeping gas.

2. The GC-IMS system of claim 1 , wherein:
the IMS further comprises: an electrode disposed substantially between the ionization region and the reaction region and configured to generate an electric field for moving positive ions or negative ions of the ions generated in the ionization region into the reaction region.

3. The GC-IMS system of claim 1 , wherein:
the IMS comprises a dual-mode IMS comprising two reaction regions adjacent to the ionization region, and
the IMS further comprises: two electrodes respectively disposed substantially between the ionization region and one of the two reaction regions and between the ionization region and the other of the two reaction regions, and configured to generate electric fields for respectively moving positive ions and negative ions of the ions generated in the ionization region into the two reaction regions.

4. The GC-IMS system of claim 2 , wherein:
the electrode has a horn shape.

5. The GC-IMS system of claim 3 , wherein:
the electrode has a horn shape.

6. The GC-IMS system of claim 3 , wherein:
the sample transfer device further comprises:
a conduit for transferring the sample; and
a flow divider valve disposed on the conduit and configured to adjust amounts of the sample to be respectively transferred to the two reaction regions.

7. The GC-IMS system of claim 1 , wherein:
the gas comprises a carrier gas.

8. The GC-IMS system of claim 7 , wherein:
the carrier gas comprises air or nitrogen gas.

9. An IMS, comprising:
an ionization region for ionizing a gas to generate ions,
a reaction region which is adjacent to and different from the ionization region, is disposed downstream of the ionization region in an ion drift direction, and is configured for combining the ions with a sample,
a sample transfer device configured to transfer the sample to the reaction region directly by bypassing the ionization region, and
a sweeping gas inlet configured to flow a sweeping gas with no sample through the ionization region into the reaction region, wherein the ions generated in the ionization region are moved to the reaction region under a sweeping action of the sweeping gas.

10. The IMS of claim 9 , further comprising:
an electrode disposed substantially between the ionization region and the reaction region and configured to generate an electric field for moving positive ions or negative ions of the ions generated in the ionization region into the reaction region.

11. The IMS of claim 9 , further comprising:
a dual-mode IMS comprising two reaction regions adjacent to the ionization region, and
two electrodes respectively disposed substantially between the ionization region and one of the two reaction regions and between the ionization region and the other of the two reaction regions and configured to generate electric fields for respectively moving positive ions and negative ions of the ions generated in the ionization region into the two reaction regions.

12. The IMS of claim 10 , wherein:
the electrode has a horn shaped shape.

13. The IMS of claim 11 , wherein:
the electrode has a horn shaped shape.

14. The IMS of claim 9 , wherein:
the gas comprises a carrier gas.

15. The GC-IMS system of claim 1 , wherein:
the IMS further comprises an ionization source that is a radioactive source.

16. The IMS of claim 9 , further comprising:
an ionization source that is a radioactive source.

Assignees

• Nuctech Co Ltd

Inventors

• Zhang Qingjun
• Li Yuanjing
• Chen Zhiqiang
• Ma Qiufeng
• Zhao Ziran
• Liu Yinong
• Liu Yaohong
• Zou Xiang
• Wang Yanchun
• Wang Junxiao
• Chang Jianping

Classifications

• H01J49/0422

  for gaseous samples (interfaces to gas chromatographs G01N30/7206) · CPC title

• G01N27/622

  Ion mobility spectrometry · CPC title

• G01N27/64

  using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber · CPC title

• G01N30/7206 Primary

  interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title