Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
US9511056B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9511056-B2 |
| Application number | US-201414280478-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 16, 2014 |
| Priority date | May 13, 2009 |
| Publication date | Dec 6, 2016 |
| Grant date | Dec 6, 2016 |
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The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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The invention claimed is: 1. A method of eliminating hepatitis C virus in a human patient in need thereof comprising administering to said human an effective amount of: (1) a compound of formula: and (2) a NS5B polymerase inhibitor. 2. The method of claim 1 , wherein the NS5B polymerase inhibitor is a nucleotide inhibitor of HCV NS5B polymerase. 3. The method of claim 2 , wherein the human is treated without interferon. 4. The method of claim 3 , wherein the human is treated without ribavirin. 5. The method of claim 3 , wherein the human is treated with ribavirin. 6. The method of claim 3 , wherein the human is infected with HCV genotype 1. 7. The method of claim 3 , wherein the human is infected with HCV genotype 1a or 1b. 8. The method of claim 4 , wherein the human is infected with HCV genotype 1. 9. The method of claim 4 , wherein the human is infected with HCV genotype 1a or 1b.
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