Ion transfer method and device

Patent metadata

Field	Value
Publication number	US-9508538-B2
Application number	US-201615131156-A
Country	US
Kind code	B2
Filing date	Apr 18, 2016
Priority date	Feb 3, 2015
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

An ion transport device can include a plurality of pole rod pairs arranged in parallel, and a controller. The controller configured to can be configured to apply voltages in a repeating voltage pattern of to the pole rod pairs thereby creating a plurality of potential wells capable of capturing ions, and move the repeating voltage pattern along the pole rod pairs to move captured ions along the ion transport device. The ion transport device can be incorporated into a mass spectrometer.

First claim

What is claimed is:

1. An ion transport device of a mass spectrometer, comprising:
a plurality of pole rod pairs arranged in parallel, the pole rod pairs defining a plurality of ion transport cells, each ion transport cell uniquely corresponding to a contiguous group of a fixed number of pole rod pairs, such that no two ion transport cells share a common pole rod pair; and
a controller configured to
apply voltages in a repeating voltage pattern to the pole rod pairs thereby creating a plurality of potential wells capable of capturing ions, wherein each ion transport cell receives the same pattern of voltages;
apply RF potentials to the pole rods such that each pole rod pair includes a first pole rod having a RF+ polarity and a second pole rod having an RF− polarity;
move the repeating voltage pattern along the pole rod pairs to move captured ions within and between the plurality of ion transport cells along the ion transport device; and
apply at least one ejection voltage to one or more electrodes to cause ions to be ejected from the ion transport device in a direction parallel to the pole rods.

2. The ion transport device of claim 1 , wherein the spacing between pole rods of a pole rod pair is greater than the spacing between pole rod pairs.

3. The ion transport device of claim 1 , wherein the spacing between pole rod pairs is substantially equal along the length of the ion transport device.

4. The ion transport device of claim 1 , wherein the spacing between pole rods of a pole rod pair is between two and four times greater than the spacing between pole rod pairs.

5. The ion transport device of claim 1 , wherein the repeating voltage pattern is a stepped voltage pattern.

6. The ion transport device of claim 1 , wherein the repeating voltage pattern is a pattern of continuously varying voltage levels.

7. The ion transport device of claim 1 , wherein the ion transport device is positioned and oriented to receive ions in a direction parallel to the primary axes of the pole rods.

8. A mass spectrometer, comprising:
an ion transport device including a plurality of pole rod pairs arranged in parallel, the pole rod pairs defining a plurality of ion transport cells, each ion transport cell uniquely corresponding to a contiguous group of a fixed number of pole rod pairs, such that no two ion transport cells share a common pole rod pair; and
a controller configured to
apply voltages in a repeating voltage pattern to the pole rod pairs thereby creating a plurality of potential wells capable of capturing ions, wherein each ion transport cell receives the same pattern of voltages;
move the repeating voltage pattern along the pole rod pairs to move captured ions within and between the plurality of ion transport cells along the ion transport device; and
apply at least one ejection voltage to one or more electrodes to cause ions to be ejected from the ion transport device in a direction parallel to the pole rods,

wherein the ion transport device is positioned and oriented to receive ions travelling in a direction parallel to the primary axes of the pole rods.

9. The mass spectrometer of claim 8 , wherein the ions are transported along the ion transport device in a direction perpendicular to the primary axes of the pole rods.

10. The mass spectrometer of claim 8 , wherein the spacing between pole rods of a pole rod pair is greater than the spacing between pole rod pairs.

11. The mass spectrometer of claim 8 , wherein the spacing between pole rod pairs is substantially equal along the length of the ion transport device.

12. The mass spectrometer of claim 8 , wherein the spacing between pole rods of a pole rod pair is between two and four times greater than the spacing between pole rod pairs.

13. The mass spectrometer of claim 8 , wherein the repeating voltage pattern is a stepped voltage pattern.

14. The mass spectrometer of claim 13 , wherein the stepped voltage pattern is a pattern of High-Low-High applied across three pole rod pairs.

15. The mass spectrometer of claim 13 , wherein the stepped voltage pattern is a pattern of High-Low-Low-High applied across four pole rod pairs.

16. The mass spectrometer of claim 13 , wherein the stepped voltage pattern is a pattern of High-Low-Low-Low-High applied across five pole rod pairs.

17. The mass spectrometer of claim 8 , wherein the repeating voltage pattern is a pattern of continuously varying voltage levels.

18. The mass spectrometer of claim 17 , wherein the pattern of continuously varying voltage levels is applied across three pole rod pairs and is defined by V1(t)=+V*cos(Pi/4−ω*t), V2(t)=−V*cos(Pi/4−ω*t), V3(t)=+V*cos(Pi/4−ω*t).

19. The mass spectrometer of claim 17 , wherein the pattern of continuously varying voltage levels is applied across four pole rod pairs and is defined by V1(t)=V*cos(ω*t−Pi/4), V2(t)=V*sin(ω*t−Pi/4), V3(t)=−V*cos(ω*t−Pi/4), V4(t)=−V*sin(ω*t−Pi/4).

20. The mass spectrometer of claim 17 , wherein the pattern of continuously varying voltage levels is applied across five pole rod pairs and is defined by V1(t)=V*cos(ω*t−Pi/5), V2(t)=−V*cos(ω*t+(2/5)*Pi), V3(t)=−V*cos(ω*t), V4(t)=−V*cos(ω*t−(2/5)*Pi), V5(t)=V*cos(ω*t+Pi/5).

Assignees

• Thermo Finnigan Llc

Inventors

• Kovtoun Viatcheslav V

Classifications

• H01J49/062 Primary

  Ion guides (linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421) · CPC title

• H01J49/004

  Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn · CPC title

• H01J49/423

  with radial ejection · CPC title

• H01J49/0045 Primary

  characterised by the fragmentation or other specific reaction · CPC title

• H01J49/4235

  Stacked rings or stacked plates · CPC title