Method for preparing gold nanocluster composition

Patent metadata

Field	Value
Publication number	US-9506864-B2
Application number	US-201414582428-A
Country	US
Kind code	B2
Filing date	Dec 24, 2014
Priority date	Nov 6, 2014
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

A gold nanocluster composition and method for preparing the same are provided. The method includes providing a gold ion-containing solution. Next, the method entails mixing the gold ion-containing solution and a reducing agent solution to obtain a first mixture liquid, and heating the first mixture liquid to obtain a second mixture liquid, wherein the second mixture liquid contains the gold nanoclusters, which are partially capped by reducing agent.

First claim

What is claimed is:

1. A method for preparing a gold nanocluster composition, comprising:
mixing a gold ion-containing solution and a reducing agent solution to obtain a first mixture liquid; and
heating the first mixture liquid to obtain a second mixture liquid,
wherein the second mixture liquid contains a gold nanocluster composition, and the gold nanoclusters are partially capped by reducing agent, and wherein
when the step of heating the first mixture liquid is performed by microwave heating with a microwave power of 270 W to 450 W and the gold ions and the reducing agent have a molar ratio of 1:1 to 1:1.2, the gold nanocluster compositions have fluorescence emission peaks at wavelength of 600-650 nm and 800-850 nm,
when the step of heating the first mixture liquid is performed by dry bath heating with a temperature of 100° C. to 200° C. and the gold ions and the reducing agent have a molar ratio of 1:1.1 to 1:1.4, the gold nanocluster compositions have fluorescence emission peaks at wavelength of 600-650 nm and 800-850 nm, and
when the step of heating the first mixture liquid is performed by microwave heating with a microwave power of 270 W to 450 W and the gold ions and the reducing agent have a molar ratio of 1:0.7 to 1:0.8, the gold nanocluster composition has a single fluorescence emission peak at wavelength of 800-900 nm.

2. The method as claimed in claim 1 , wherein the reducing agent comprises glutathione.

3. The method as claimed in claim 1 , wherein the gold ion-containing solution comprises chloroauric acid solution, auric chloride solution, gold sulfide solution, or a combination thereof.

4. The method as claimed in claim 1 , wherein the step of heating the first mixture liquid is performed for a period of 10 minutes to 60 minutes.

5. The method as claimed in claim 1 , further comprising a step of centrifuging the second mixture liquid and collect the supernatant for obtaining the gold nanocluster compositions.

Assignees

• Ind Tech Res Inst

Inventors

• Chen Cheng-Tai
• Jiang Pei-Shin
• Chen Ting-Shou
• Tsai Jane S-C

Classifications

• G01N21/6428 Primary

  Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53) · CPC title

• Y10S977/896

  Chemical synthesis, e.g. chemical bonding or breaking · CPC title

• B82Y20/00

  Nanooptics, e.g. quantum optics or photonic crystals · CPC title

• C09K2211/10

  Non-macromolecular compounds · CPC title

• Y10S977/95

  Electromagnetic energy · CPC title