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Efficient method for establishing induced pluripotent stem cells
US9506039B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9506039-B2 |
| Application number | US-201113991341-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 2, 2011 |
| Priority date | Dec 3, 2010 |
| Publication date | Nov 29, 2016 |
| Grant date | Nov 29, 2016 |
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Abstract
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The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods.
First claim
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The invention claimed is: 1. A method of producing induced pluripotent stem cells, comprising contacting a somatic cell with a nuclear reprogramming substance(s) and a nucleic acid vector(s) encoding one or more AKT family members, thereby producing functionally pluripotent stem cells, wherein the nuclear reprogramming substance(s) comprises a nucleic acid vector encoding Oct3/4 and optionally comprises a nucleic acid vector(s) encoding one or more substances selected from the gro…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9506039B2 cover?
- The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of produci…
- Who is the assignee on this patent?
- Yamanaka Shinya, Takahashi Kazutoshi, Tanabe Koji, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0696. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 29 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).