Genes and proteins associated with angiogenesis and uses thereof

Patent metadata

Field	Value
Publication number	US-9505819-B2
Application number	US-201314099433-A
Country	US
Kind code	B2
Filing date	Dec 6, 2013
Priority date	Sep 30, 2005
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying compounds useful for regulating angiogenesis and conditions related thereto are disclosed.

First claim

What is claimed is:

1. A method to inhibit angiogenesis in tumor cells produced from fibrosarcoma in a patient in need thereof, comprising increasing the expression or biological activity of Lumican in the tumor cells, wherein the step increasing comprises contacting the tumor cells with a recombinant nucleic acid molecule encoding Lumican or a homologue thereof to increase expression of Lumican in the tumor cells.

2. The method of claim 1 , wherein the step of increasing comprises contacting the tumor cells with a recombinant nucleic acid molecule encoding Lumican.

Assignees

• Nat Jewish Health

Inventors

• Schiemann William P
• Albig Allan R

Classifications

• G01N33/5011

  for testing antineoplastic activity · CPC title

• G01N33/5017

  for testing neoplastic activity · CPC title

• C07H21/04

  with deoxyribosyl as saccharide radical · CPC title

• G01N2500/00

  Screening for compounds of potential therapeutic value · CPC title

• A61K48/00

  Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy · CPC title