P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof
US-2024400592-A1 · Dec 5, 2024 · US
US9505740B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9505740-B2 |
| Application number | US-201415024185-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 26, 2014 |
| Priority date | Sep 26, 2013 |
| Publication date | Nov 29, 2016 |
| Grant date | Nov 29, 2016 |
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A compound exerts a strong analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The cyclic amine derivative is represented by formula, a prodrug thereof or a pharmacologically acceptable salt thereof: wherein A represents a group represented by Formula (IIa), (IIb) or (IIc): wherein R 3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R 4 represents a hydrogen atom or an alkylcarbonyl group having 2 to 6 carbon atoms or an alkyl group having 1 to 6 carbon atoms and optionally substituted with an alkylcarbonylamino group having 2 to 6 carbon atoms and n represents 1 or 2, in which when R 3 and R 4 each independently represent an alkyl group having 1 to 6 carbon atoms, R 1 represents an alkyl group having 1 to 6 carbon atoms and substituted with a hydroxyl group, an amino group or a carboxyl group.
Opening claim text (preview).
The invention claimed is: 1. A cyclic amine derivative represented by Formula (I), a prodrug of the derivative, or a pharmacologically acceptable salt thereof: wherein A represents a group represented by Formula (IIa), (IIb) or (IIc): wherein when A represents a gr…
Chemistry & Metallurgy · mapped topic
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