Oral care formulations for malodor control

Patent metadata

Field	Value
Publication number	US-9504857-B2
Application number	US-201113522563-A
Country	US
Kind code	B2
Filing date	Jan 28, 2011
Priority date	Jan 29, 2010
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

Described herein are oral care compositions comprising an orally acceptable carrier; and a film, wherein said film comprises an odor controlling active; a mucoadhesive polymer; a release-rate modulating polymer; a polymeric base; and optionally a flavorant; and wherein said film controls release of said odor controlling active.

First claim

The invention claimed is:

1. An oral care composition comprising
an orally acceptable carrier, and
a multilayer film, wherein
the multilayer film is entrained in the orally acceptable carrier, and wherein said multilayer film comprises at least one mucoadhesive layer and one overlying layer, and
wherein the mucoadhesive layer comprises:
a mucoadhesive polymer,
a first polymeric base, and
an odor controlling active; and

wherein the overlying layer comprises:
a release modulating polymer,
a second polymeric base, and

optionally a flavorant;
wherein said odor controlling active is a zinc containing compound selected from the group consisting of: zinc oxide; zinc citrate; zinc lactate; zinc chlorite; zinc chloride; zinc zeolite; and a combination of two or more thereof;

wherein the mucoadhesive polymer is selected from the group consisting of a polyacrylic acid or polyacrylate, a cross-linked polyacrylic acid or polyacrylate, a polyalkyl acrylate, a cross-linked polyalkyl acrylate, polyvinylpyrrolidone, a copolymer of polyvinylpyrrolidone and polyacrylate, chitosan or a chemically-modified chitosan, and a combination of two or more thereof;
wherein the release modulating polymer is polyvinyl acetate or hydroxyl ethyl cellulose;
wherein either or both of the first polymeric base and second polymeric base is selected from the group consisting of: hydroxypropylmethyl cellulose; methyl cellulose; hydroxypropyl cellulose; and copolymers thereof;
wherein the mucoadhesive polymer comprises from 2% to 5% by weight of the mucoadhesive layer; and wherein the multilayer film comprises from 0.1% to 5% by weight of the oral care composition.

2. The composition of claim 1 , wherein the release modulating polymer comprises from 20% to 30% by weight of the overlying layer.

3. The composition of claim 1 , wherein the first polymeric base comprises from 25% to 50% by weight of the multilayer film.

4. The composition of claim 1 , wherein the second polymeric base comprises from 25% to 50% by weight of the multilayer film.

5. The composition of claim 1 , wherein the odor controlling active comprises from 30% to 40% by weight of the mucoadhesive layer.

6. A method for treating or preventing oral malodor comprising: administering to a subject in need thereof, a controlled release oral care composition according to claim 1 .

7. An oral care composition comprising
an orally acceptable carrier, and
a multilayer film, wherein
the multilayer film is entrained in the orally acceptable carrier, and wherein said multilayer film comprises at least one mucoadhesive layer and one overlying layer, and
wherein the mucoadhesive layer comprises:
a mucoadhesive polymer,
a first polymeric base, and
an odor controlling active; and

wherein the overlying layer comprises:
a release modulating polymer,
a second polymeric base, and
optionally a flavorant;

wherein said odor controlling active is a zinc containing compound selected from the group consisting of: zinc oxide; zinc citrate; zinc lactate; zinc chlorite; zinc chloride; zinc zeolite; and a combination of two or more thereof;
wherein the mucoadhesive polymer is selected from the group consisting of a polyacrylic acid or polyacrylate, a cross-linked polyacrylic acid or polyacrylate, a polyalkyl acrylate, a cross-linked polyalkyl acrylate, polyvinylpyrrolidone, a copolymer of polyvinylpyrrolidone and polyacrylate, chitosan or a chemically-modified chitosan, and a combination of two or more thereof;
wherein the release modulating polymer is polyvinyl acetate or hydroxyl ethyl cellulose;
wherein either or both of the first polymeric base and second polymeric base is selected from the group consisting of: hydroxypropylmethyl cellulose; methyl cellulose; hydroxypropyl cellulose; and copolymers thereof;
wherein the mucoadhesive polymer comprises from 2% to 5% by weight of the mucoadhesive layer;
wherein the release modulating polymer comprises from 20% to 30% by weight of the overlying layer;
wherein the first polymeric base comprises from 25% to 50% by weight of the multilayer film;
wherein the second polymeric base comprises from 25% to 50% by weight of the multilayer film;
wherein the odor controlling active comprises from 30% to 40% by weight of the mucoadhesive layer; and
wherein the multilayer film comprises from 0.1% to 5% by weight of the oral care composition.

8. The composition of claim 1 , wherein the composition comprises two phases, wherein one phase comprises the orally acceptable carrier and the second phase comprises the multilayer film.

Assignees

• Boyd Thomas
• Leigh Leonora
• Colgate Palmolive Co

Inventors

• Boyd Thomas
• Leigh Leonora

Classifications

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A61K8/8152

  Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers · CPC title

• A61K8/0233

  Distinct layers, e.g. core/shell sticks · CPC title

• A61K8/731

  Cellulose; Quaternized cellulose derivatives · CPC title

• A61Q11/00 Primary

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title