Methods, systems, and devices for pairing vagus nerve stimulation with motor therapy in stroke patients

Patent metadata

Field	Value
Publication number	US-9504831-B2
Application number	US-201414538457-A
Country	US
Kind code	B2
Filing date	Nov 11, 2014
Priority date	Jul 2, 2008
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

First claim

What is claimed is:

1. A method of improving motor deficits in a stroke patient, the method comprising:
stimulating a vagus nerve of the patient by delivering pulse trains of artificial electrical stimulation energy from a stimulation device to the vagus nerve while the patient is performing a movement of a therapeutic task;
terminating the stimulation of the vagus nerve so that there is no stimulation between movement execution; and
improving the patient's motor deficits,
wherein the action of stimulating the vagus nerve of the patient further comprises determining respective beginnings of performances of the therapeutic task, and applying the pulse trains to the vagus nerve based on the determined beginnings of the performances, wherein the vagus nerve stimulation pulse trains begin after the beginning of the respective therapeutic tasks, wherein the vagus nerve stimulation pulse trains end prior to the end of the respective therapeutic tasks, and wherein the vagus nerve stimulation pulse train is not presented between performances of the therapeutic task.

2. The method of claim 1 , wherein the pulse trains are about 500 milliseconds in duration.

3. The method of claim 1 , wherein the pulse trains have an amplitude of about 0.8 milliamperes.

4. The method of claim 1 , wherein a therapeutic task level is selected for each therapeutic task and the therapeutic task level is changed between repetitive performances of the therapeutic task.

5. A method of improving motor deficits in a stroke patient, the method comprising:
stimulating a vagus nerve of the patient by delivering pulse trains of electrical stimulation energy from a stimulation device to the vagus nerve while the patient is performing a movement of a therapeutic task;
terminating the stimulation of the vagus nerve; and
improving the patient's motor deficits,
wherein the action of stimulating the vagus nerve of the patient further comprises determining respective beginnings of performances of the therapeutic task, and applying the pulse trains to the vagus nerve based on the determined beginnings of the performances, wherein the vagus nerve stimulation pulse trains begin after the beginning of the respective therapeutic tasks, wherein the vagus nerve stimulation pulse trains end prior to the end of the respective therapeutic tasks, and wherein the vagus nerve stimulation pulse train is not presented between performances of the therapeutic task.

6. The method of claim 5 , wherein the pulse trains are about 500 milliseconds in duration.

7. The method of claim 5 , wherein the pulse trains have an amplitude of about 0.8 milliamperes.

8. The method of claim 5 , wherein a therapeutic task level is selected for each therapeutic task and the therapeutic task level is changed between repetitive performances of the therapeutic task.

Assignees

• Microtransponder Inc
• Univ Texas

Inventors

• Kilgard Michael P
• Engineer Navzer
• Pierce David Michael
• Rennaker Robert L

Classifications

• A61N1/37217

  characterised by the communication link, e.g. acoustic or tactile · CPC title

• A61N1/36103

  Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke · CPC title

• A61B5/1124

  Determining motor skills · CPC title

• G09B23/28

  for medicine · CPC title

• A61N1/36132

  using patient feedback · CPC title