Cardiac-specific protein targeting domain
US-9249184-B2 · Feb 2, 2016 · US
US9504732B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9504732-B2 |
| Application number | US-201414760494-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 14, 2014 |
| Priority date | Jan 14, 2013 |
| Publication date | Nov 29, 2016 |
| Grant date | Nov 29, 2016 |
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The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
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The invention claimed is: 1. A method for reducing infarct size and reperfusion arrhythmias in a patient in need thereof, said patient having had a myocardial infarction, comprising the steps of i) restoring blood supply in cardiac ischemic tissue of the patient, and ii) inducing cardioprotection by administering to the patient a therapeutically effective amount of a ligand of the sonic hedgehog signaling pathway, wherein the step of inducing cardioprotection causes a reductio…
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