Methods using desmopressin acetate in orodispersible form
US-9220747-B2 · Dec 29, 2015 · US
US9504647B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9504647-B2 |
| Application number | US-201514947261-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 20, 2015 |
| Priority date | May 7, 2002 |
| Publication date | Nov 29, 2016 |
| Grant date | Nov 29, 2016 |
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Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form. Preferred dosage forms comprise desmopressin and an open matrix network which is an inert water-soluble or water-dispersible carrier material. Desmopressin formulated in this way is useful for voiding postponement, or the treatment or prevention of incontinence, primary noctural enuresis (PNE), nocturia or central diabetes insipidus. Peptides other than desmopressin can also be formulated in this way.
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The invention claimed is: 1. A solid orodispersible pharmaceutical dosage form of desmopressin acetate, comprising desmopressin acetate in an open matrix network carrying the desmopressin acetate, wherein the open matrix network comprises a water-soluble or water-dispersible carrier material inert to the desmopressin acetate that comprises gelatin, and wherein the dosage form disintegrates in the mouth within 10 seconds. 2. The dosage form of clam 1 , wherein t…
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