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Methods of manufacture and use of implantable pressure-actuated drug delivery systems

US9504586B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9504586-B2
Application numberUS-201414179835-A
CountryUS
Kind codeB2
Filing dateFeb 13, 2014
Priority dateJan 5, 2010
Publication dateNov 29, 2016
Grant dateNov 29, 2016

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.

First claim

Opening claim text (preview).

What is claimed is: 1. A method of using a pressure-actuated substance delivery system, wherein the pressure-actuated substance delivery system includes a substrate, a substance within a pressurized cavity of the substrate, a frangible layer disposed over a surface of the substrate, including over an opening to the cavity, and a substantially non-frangible layer of an implant-environment-dissipative material disposed over the frangible layer, wherein the frangible layer has a ruptu…

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Frequently asked questions

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What does patent US9504586B2 cover?
Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may …
Who is the assignee on this patent?
Univ Johns Hopkins
What technology area does this patent fall under?
Primary CPC classification A61F2/82. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Nov 29 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).