Sample dispenser including an internal standard and methods of use thereof

Patent metadata

Field	Value
Publication number	US-9500572-B2
Application number	US-201313784094-A
Country	US
Kind code	B2
Filing date	Mar 4, 2013
Priority date	Apr 30, 2009
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. In certain embodiments, the invention provides a fluid dispenser that includes a fluid chamber. A portion of an inner wall of the chamber includes an internal standard. The chamber is configured such that fluid introduced to the chamber must interact with the portion of the chamber wall that includes the internal standard prior to flowing through an outlet of the chamber. The dispenser additionally includes a member coupled to the chamber such that it can control movement of fluid within the chamber.

First claim

What is claimed is:

1. A fluid dispensing system, the system comprising:
an elongated inlet configured to extend external to the fluid dispensing system, wherein an entirety of only an inner wall of the elongated inlet comprises an internal standard, the elongated inlet being configured such that fluid introduced to the elongated inlet must interact with the entirety of the inner wall of the elongated inlet that comprises the internal standard prior to flowing through an outlet of the fluid dispensing system; and
a dispenser that couples to an external wall of the elongated inlet and controls movement of fluid within the elongated inlet.

2. The system according to claim 1 , wherein the elongated inlet is an elongated tube.

3. The system according to claim 2 , wherein the tube is a capillary tube.

4. The system according to claim 2 , wherein the internal standard coats an entirety of the inner walls of the tube.

5. The system according to claim 2 , wherein the dispenser controls movement through application of pneumatic pressure.

6. The system according to claim 5 , wherein the dispenser is a compressible hollow bulb.

7. The system according to claim 1 , wherein the outlet is also the inlet for the fluid.

Assignees

• Purdue Research Foundation

Inventors

• Ouyang Zheng
• Wang He
• Manicke Nicholas E
• Cooks Robert Graham
• Yang Qian
• Liu Jiangjiang

Classifications

• G01N2001/2893

  Preparing calibration standards · CPC title

• G01N1/286 Primary

  involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising (microtomes G01N1/06; pulverising in general B02C; mixing in general B01F) · CPC title

• G01N1/10

  in the liquid or fluent state {(burettes, pipettes B01L3/02; sampling of ground water E02D1/06; metering by volume of fluids or fluent solid material G01F11/00, G01F13/00)} · CPC title

• H01J49/0009

  Calibration of the apparatus · CPC title

• H01J49/16

  using surface ionisation, e.g. field-, thermionic- or photo-emission · CPC title