Nanofiber Structures and Methods of Use Thereof
US-2019209732-A1 · Jul 11, 2019 · US
Two-component tissue adhesive and method for producing same
US9499728B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9499728-B2 |
| Application number | US-201113877880-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 4, 2011 |
| Priority date | Oct 5, 2010 |
| Publication date | Nov 22, 2016 |
| Grant date | Nov 22, 2016 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention addresses the problem of providing: a two-component tissue adhesive having high adhesive strength and high biocompatibility; and a method for producing the two-component tissue adhesive. The present invention involves a two-component tissue adhesive comprising hydrophobically-modified gelatin as a first agent and a cross-linking reagent as a second agent. The hydrophobically-modified gelatin is provided with an amino group and a hydrophobic group on the side chain thereof, and the cross-linking reagent has two or more active ester groups or anhydrides within a single molecule.
First claim
Opening claim text (preview).
The invention claimed is: 1. A two-component tissue adhesive composition consisting of a hydrophobically-modified gelatin comprising at least one hydrophobic cholesteryl group linked to lysine residue side chains of polypeptide of said gelatin; and a cross-linking reagent that is disuccinimidyl tartrate; wherein ratio of succinimidyl group within said disuccinimidyl tartrate to amino group of said lysine residue are between 1:1 and 2:1, molecular weight of said gelatin is between 10 KDa and about 20 KDa; and wherein adhesive strength of said composition is at least 50 kPa. 2. The two-component tissue adhesive according to claim 1 , wherein said first agent further contains gelatin which is any one type or a combination of two or more types selected from the group consisting of natural gelatin derived from human, porcine, bovine, or fish species, and genetically modified gelatin thereof.
Assignees
Inventors
Classifications
- A61L24/104Primary
Gelatin · CPC title
- C09J189/00Primary
Adhesives based on proteins; Adhesives based on derivatives thereof · CPC title
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Frequently asked questions
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- What does patent US9499728B2 cover?
- The present invention addresses the problem of providing: a two-component tissue adhesive having high adhesive strength and high biocompatibility; and a method for producing the two-component tissue adhesive. The present invention involves a two-component tissue adhesive comprising hydrophobically-modified gelatin as a first agent and a cross-linking reagent as a second agent. The hydrophobical…
- Who is the assignee on this patent?
- Taguchi Tetsushi, Matsuda Miyuki, Nat Inst For Materials Science
- What technology area does this patent fall under?
- Primary CPC classification A61L24/104. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 22 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).