Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations

Patent metadata

Field	Value
Publication number	US-9499636-B2
Application number	US-201313927316-A
Country	US
Kind code	B2
Filing date	Jun 26, 2013
Priority date	Jun 28, 2012
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.

First claim

What is claimed is:

1. A process comprising:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose;
adjusting the swelled oxidized cellulose to a first temperature from about 115° C. to 145° C.;
contacting the swelled oxidized cellulose with a salt under the inert atmosphere to form an oxidized cellulose solution;
adjusting the oxidized cellulose solution to a second temperature from about 90° C. to about 120° C.; and
contacting the oxidized cellulose solution with at least one multivalent cation selected from cations of calcium, barium, zinc, magnesium, chromium, platinum, or iron to form a plurality of oxidized cellulose particles.

2. The process according to claim 1 , further comprising shearing the oxidized cellulose solution to form the plurality of oxidized cellulose particles.

3. The process according to claim 1 , wherein the solvent is selected from the group consisting of N,N-Dimethylacetamide, N-methyl-2-pyrrolidinone, and combinations thereof.

4. The process according to claim 1 , wherein the salt is selected from the group consisting of lithium halides, sodium halides, potassium halides, and combinations thereof.

5. The process according to claim 1 , wherein the plurality of oxidized cellulose particles include oxidized cellulose having a degree of oxidation from about 80% to about 120% of a degree of oxidation of the predissolved oxidized cellulose.

6. The process according to claim 1 , wherein the plurality of oxidized cellulose particles include oxidized cellulose having a molecular weight from about 80% to about 120% of the molecular weight of the predissolved oxidized cellulose.

7. A process comprising:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose having a degree of oxidation of from about 0.2 to about 1.0;
adjusting the swelled oxidized cellulose to a first temperature from about 120° C. to about 140° C.;
contacting the swelled oxidized cellulose with a salt under the inert atmosphere to form an oxidized cellulose solution;
adjusting the oxidized cellulose solution to a second temperature from about 100° C. to about 110° C.; and
contacting the oxidized cellulose solution with at least one multivalent cation selected from cations of calcium, barium, zinc, magnesium, chromium, platinum, or iron to form a plurality of oxidized cellulose particles having a degree of oxidation from about 80% to about 120% of the degree of oxidation of the predissolved oxidized cellulose.

8. The process according to claim 7 , further comprising shearing the oxidized solution to form the plurality of oxidized cellulose particles.

9. The process according to claim 7 , wherein the solvent is selected from the group consisting of N,N-Dimethylacetamide, N-methyl-2-pyrrolidinone, and combinations thereof.

10. The process according to claim 7 , wherein the salt is selected from the group consisting of lithium halides, sodium halides, potassium halides, and combinations thereof.

11. A process comprising:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose;
adjusting the swelled oxidized cellulose to a first temperature from about 120° C. to about 140° C.;
contacting the swelled oxidized cellulose with a salt under the inert atmosphere to form an oxidized cellulose solution;
adjusting the oxidized cellulose solution to a second temperature from about 100° C. to about 110° C.; and
contacting the oxidized cellulose solution with at least one multivalent cation selected from cations of calcium, barium, zinc, magnesium, chromium, platinum, or iron to form a plurality of oxidized cellulose particles having a molecular weight from about 80% to about 100% of the molecular weight of the predissolved oxidized cellulose.

12. The process according to claim 11 , wherein the solvent is selected from the group consisting of N,N-Dimethylacetamide, N-methyl-2-pyrrolidinone, and combinations thereof.

13. The process according to claim 11 , wherein the salt is selected from the group consisting of lithium halides, sodium halides, potassium halides, and combinations thereof.

14. The process according to claim 11 , further comprising shearing the oxidized cellulose solution to form the plurality of oxidized cellulose particles.

Assignees

• Confluent Surgical Inc
• Covidien Lp

Inventors

• Blaskovich Phillip
• Tramontano Valentino
• Ohri Rachit
• Costa Daniel S
• Kennedy Joshua
• Farooqi Sajida

Classifications

• C08J3/14

  by precipitation from solutions {(C08J3/122 takes precedence)} · CPC title

• C08B15/00 Primary

  Preparation of other cellulose derivatives or modified cellulose {, e.g. complexes} · CPC title

• C08B15/005

  Crosslinking of cellulose derivatives · CPC title

• C08J3/096

  Nitrogen containing compounds · CPC title

• C08B1/003 Primary

  Preparation of cellulose solutions, i.e. dopes, with different possible solvents, e.g. ionic liquids (solutions used in the manufacture of monocomponent artificial filaments or cellulose or derivatives thereof D01F2/02) · CPC title