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US-2024197832-A1 · Jun 20, 2024 · US
Use of proteases for gluten intolerance
US9498520B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9498520-B2 |
| Application number | US-201514593203-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 9, 2015 |
| Priority date | Feb 2, 2010 |
| Publication date | Nov 22, 2016 |
| Grant date | Nov 22, 2016 |
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- Title
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Abstract
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The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce exposure to gluten oligopeptides.
First claim
Opening claim text (preview).
We claim: 1. A method of treating gluten intolerance or reducing gluten exposure in a human subject comprising: orally administering the subject with a therapeutically effective amount of an enzyme cocktail comprising a gluten degrading enzyme preparation isolated from Aspergillus oryzae with specificity for peptide substrate leucyl-glycyl-glycine (GDEP-LGG), papain, a semi-alkali protease and an enzyme preparation from Penicillium citrinum, wherein the enzyme cocktail degrades a gluten oligopeptide of SEQ ID NO:1 into peptide fragments of four amino acids or less at acidic conditions, and wherein the GDEP-LGG and papain are in a percent relative activity ratio of 80:20 to 20:80. 2. The method of claim 1 , wherein the enzyme cocktail is formulated in a pharmaceutically acceptable excipient. 3. The method of claim 1 , wherein the semi-alkali protease is Protease P. 4. The method of claim 1 , wherein the papain has been activated by a reductant. 5. The method of claim 1 , wherein the percent relative activity ratio is 80:20 to 40:60. 6. The method of claim 1 , wherein the percent relative activity ratio is 80:20 to 60:40. 7. The method of claim 1 , wherein the percent relative activity ratio is 60:40.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Nutrients, e.g. vitamins, minerals · CPC title
Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title
Drugs for disorders of the alimentary tract or the digestive system · CPC title
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- What does patent US9498520B2 cover?
- The present technology relates to an enzyme composition. The enzyme composition may be used to treat gluten intolerant subjects, including suffering from non-Celiac gluten intolerance and/or non-Celiac gluten sensitivity. The enzyme composition may also be used to reduce gluten exposure in certain individuals. For example, the enzyme composition may also be used as a prophylactic to reduce expo…
- Who is the assignee on this patent?
- Amano Enzyme Usa Co Ltd, Amano Enzyme Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K38/4886. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 22 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).