Abradable films for use in oral care

Patent metadata

Field	Value
Publication number	US-9498418-B2
Application number	US-201214651622-A
Country	US
Kind code	B2
Filing date	Dec 14, 2012
Priority date	Dec 14, 2012
Publication date	Nov 22, 2016
Grant date	Nov 22, 2016

Abstract

The present invention relates to abradable films useful, e.g., in dentifrice formulations, wherein the film is stable in formulation, but abrades to release pigment or oral care active components upon brushing. The invention provides, e.g., an orally acceptable, water insoluble film which does not dissolve under formulation conditions but disintegrates upon brushing, comprising a polymer matrix, plasticizer (e.g., propylene glycol), releasable material (e.g., color or pigment) incorporated therein; and (optionally) nonionic surfactant (e.g. polysorbate), wherein the polymer matrix comprises at least 50%, e.g., at least 75%, of poly(vinyl alcohol), and 50% or less, e.g. 25% or less, of a water-soluble cellulose ether, for example hydroxypropyl methyl cellulose; together with dentifrice comprising such films, and methods of making and using the same.

First claim

What is claimed is:

1. A dentifrice comprising particles of orally acceptable, water-insoluble film, which disintegrates upon brushing in the presence of water, the film comprising a polymer matrix, a releasable material incorporated therein, and a plasticizer, wherein the polymer matrix comprises at least 50% of poly(vinyl alcohol), and 50% or less of a water-soluble cellulose ether and is further characterized in that the film does not disintegrate in the absence of brushing and wherein the film does not dissolve when placed in water sufficient to cover the film, at room temperature, for a period of at least 24 hours, and upon application to the oral cavity and brushing, the film disintegrates and releases the releasable material following at least 30 seconds and not more than about 180 seconds.

2. The dentifrice according to claim 1 , wherein the releasable material is a pigment or combination of pigments.

3. The dentifrice according to claim 1 wherein the water-soluble cellulose ether is a hydroxyalkyl cellulose or mixture of hydroxyalkyl celluloses.

4. The dentifrice according to claim 1 wherein the water-soluble cellulose ether is hydroxypropyl methyl cellulose.

5. The dentifrice according to claim 1 wherein the plasticizer is a polyalcohol selected from sorbitol, propylene glycol, glycerol, polyethylene glycol, and mixtures thereof.

6. The dentifrice according to claim 1 wherein the plasticizer is propylene glycol.

7. The dentifrice according to claim 1 , the film further comprising a non-ionic surfactant or emulsifier.

8. The dentifrice according to claim 7 wherein the non-ionic surfactant or emulsifier is a polysorbate.

9. The dentifrice according to claim 1 wherein the film is coated by a powder coating which comprises a pigment.

10. The dentifrice according to claim 1 wherein the releasable material comprises a water-insoluble antimicrobial agent.

11. The dentifrice according to claim 1 wherein the average thickness of the film is 1-3 mil.

12. The dentifrice according to claim 1 wherein the polymer matrix comprises at least 75% of poly(vinyl alcohol), and 25% or less of a water-soluble cellulose ether.

13. The dentifrice according to claim 1 , the film comprising:
1-10 wt% water soluble cellulose ether;
30-60 wt% poly(vinyl alcohol);
20-60 wt% releasable material;
10-30 wt% plasticizer; and
1-5 wt% surfactant.

14. The dentifrice according to claim 1 , the film comprising:
3-7 wt% hydroxypropylmethyl cellulose (HPMC);
40-50 wt% poly(vinyl alcohol);
35-45 wt% pigment;
15-20 wt% propylene glycol; and
2-3 wt% polysorbate 80.

15. The dentifrice of claim 1 wherein the releasable material is a pigment, the release of which provides a color signal to the user of adequate brushing.

16. The dentifrice of claim 1 which is a clear gel toothpaste, in which the film particles can be seen.

17. A method of cleaning the teeth, comprising brushing with a dentifrice according to claim 1 , and thereby disrupting the film and causing release of the releasable material.

18. The method of claim 17 wherein the orally acceptable film comprises a pigment in the film, and brushing is continued until the film disintegrates and the pigment provides a color signal to the user of adequate brushing.

19. A method of manufacturing a film according to claim 1 comprising making an aqueous slurry of poly(vinyl alcohol), water-soluble cellulose ether, releasable material, plasticizer, and optionally surfactant, and drying the slurry to form a film.

Assignees

• Colgate Palmolive Co

Inventors

• Szewczyk Gregory
• Patel Neeta Atul
• Jogun Suzanne

Classifications

• A61K8/345 Primary

  containing more than one hydroxy group · CPC title

• A61K8/8129

  Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether · CPC title

• A61K8/731

  Cellulose; Quaternized cellulose derivatives · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2800/56

  Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms · CPC title