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Implantable medical devices having double walled microspheres
US9498221B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9498221-B2 |
| Application number | US-201313788879-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 7, 2013 |
| Priority date | Sep 10, 2010 |
| Publication date | Nov 22, 2016 |
| Grant date | Nov 22, 2016 |
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- Title
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- Abstract
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Abstract
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An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
First claim
Opening claim text (preview).
What is claimed is: 1. An implantable nerve guide comprising a biodegradable polymer tube having a lumen comprising (a) an inner layer comprising a biodegradable polymer, into which are embedded double-walled microspheres containing glial cell-line derived neurotrophic factor, wherein poly(lactic-co-glycolic acid) layer forms a core and the poly(lactide) layer forms a shell of the double-walled microsphere and the microspheres provide sustained release of the bioactive neurotrophic factor over at least seven days in an amount effective in promoting nerve regeneration; and (b) an outer layer comprising a biodegradable polymer without microspheres, wherein said outer layer encapsulates the inner layer. 2. The implantable medical device of claim 1 , wherein the inner biodegradable polymer layer comprises poly(caprolactone).
Assignees
Inventors
Classifications
- A61L27/18Primary
obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title
- A61B17/1128Primary
of nerves · CPC title
Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title
Coating · CPC title
Microcapsules {having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals (A61K9/2081 takes precedence; particles with a single coating comprising drug A61K9/167)} · CPC title
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- What does patent US9498221B2 cover?
- An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
- Who is the assignee on this patent?
- Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education
- What technology area does this patent fall under?
- Primary CPC classification A61L27/18. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 22 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).